不同性别早发冠心病患者临床特点对比研究  

Comparative study on clinical features in different sexes of patients with premature coronary artery disease

作　　者：李丹 郑文武 黄冬梅 刘盼 刘茜 廖双华 Li Dan;Zheng Wenwu;Huang Dongmei;Liu Pan;Liu Qian;Liao Shuanghua(Southwest Medical University,Luzhou,Sichuan 646000,China;Department of Cardiology,Affiliated Hospital, Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学,四川泸州646000 [2]西南医科大学附属医院心内科,四川泸州646000

出　　处：《现代医药卫生》2017年第23期3561-3564,共4页Journal of Modern Medicine & Health

摘　　要：目的对比研究不同性别早发冠心病(PCAD)患者的危险因素及冠状动脉病变特点。方法选取2016年1月1日至12月31日于西南医科大学附属医院心内科住院并经冠状动脉造影确诊为PCAD患者384例(PCAD组),其中男性组237例,女性组147例;选取同期行冠状动脉造影正常的260例患者作为对照组。分析各组患者常见心血管疾病危险因素[如吸烟、高血压、糖尿病、血脂异常、体质量指数(BMI)等]、生化指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A/B(ApoA/B)等,以及血尿酸(UA)、胱抑素C(CysC)、γ-谷氨酰转肽酶(γ-GGT)等]变化及冠状动脉病变特点。结果 PCAD组患者吸烟、高血压、糖尿病、血脂异常比例及BMI比例均明显高于对照组,TG、LDL-C、CysC、UA、ApoB、γ-GGT水平均明显高于对照组,HDL-C、ApoA水平均明显低于对照组患者,差异均有统计学意义(P<0.05);且男性组患者吸烟、血脂异常比例及BMI均明显高于女性组,但发病年龄明显小于女性组,高血压比例明显低于女性组,差异均有统计学意义(P<0.05);男性组UA、γ-GCT水平均明显高于女性组,女性组患者HDL-C、ApoA水平均高于男性组,差异均有统计学意义(P<0.05)。男性组患者冠状动脉病变以单支病变为主,女性组患者则主要为多支病变;男性组患者急性心肌梗死比例明显高于女性组,差异均有统计学意义(P<0.05)。结论不同性别PCAD患者的临床特点及冠状动脉病变特点存在差异。Objective〓To comparatively study the risk factors and coronary artery lesions characteristics in different sexes of patients with premature coronary artery disease(PCAD).Methods〓A total of384patients with PCAD diagnosed by coronary angiography in the Department of Cardiology,Affiliated Hospital of Southwest Medical University from January1to December31,2016were selected,including237cases in the male group and147cases in female group.Contemporaneous260cases of normal coronary angiography served as the control group.The common cardiovascular diseases risk factors(such as smoking,hypertension,diabetes,dyslipidemia,BMI,etc.),biochemical indexes such as total cholesterol(TC),triglyceride(TG),high?鄄density lipoprotein cholesterol(HDL?鄄C),low?鄄density lipoprotein cholesterol(LDL?鄄C),apoliproteinA/apoliproteinB(ApoA/B),uric acid(UA)and cysteineC(CysC)and characteristics of coronary artery lesions were analyzed in each group.Results〓The proportion of smoking,hypertension,diabetes and dyslipidemia,and BMI proportion in the PCAD group were higher than those in the control group;the levels of TG,LDL?鄄C,CysC,UA,ApoB andγ?鄄GGT were significantly higher than those in the control group,while the levels of HDL?鄄C and ApoA were significantly lower than those in the control group the difference was statistically significant(P<0.05);the proportions of smoking and dyslipidemia,and BMI in the male group were significantly higher than those in the female group,while the onset age was significantly smaller than that in the female group,the proportions of hypertension was significantly lower than that in the female group,the difference was statistically significant(P<0.05);the UA andγ?鄄GGT levels in the male group were significantly higher than those in the female group,while the HDL?鄄C and Apo A levels in the female group were higher than those in the male group,the differences were statistically significant(P<0.05).In the male group,the coronary artery lesions were mainly single vessel lesion,while which in th

关 键 词：冠心病/病理学 性别因素 心肌梗死 危险因素 生化指标 

分 类 号：R541.4[医药卫生—心血管疾病]