硫化氢延缓肾脏纤维化作用机制的研究进展  

Mechanism of hydrogen sulfide delaying renal fibrosis:research progress

作　　者：顾玉露 章晓燕 GU Yu lu1;ZHANG Xiao yan(Shanghai Nephropathy and Dialysis Institute, Shanghai 200032, China;Department ofNephrology,ZhongshanHospital,FudanUniversity, Shanghai 200032, China;Key Laboratory of Nephropathy and Blood Purification of Shanghci , Shanghci 200032 , China)

机构地区：[1]上海市肾病与透析研究所,上海200032 [2]复旦大学附属中山医院肾内科,上海200032 [3]上海市肾病与血液净化重点实验室,上海200032

出　　处：《中国临床医学》2017年第5期824-827,共4页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(81600579);科技部国家科技支撑项目(2011BAI10B03);上海市科学技术委员会自然科学基金(14ZR1406400)~~

摘　　要：硫化氢(hydrogen sulfide,H_2S)在体内是一种内源性气体信号分子,在肾脏中表达丰富,在不同生理病理条件下发挥重要调节作用。肾脏纤维化时,H_2S含量明显降低,补充外源性H_2S可明显减轻纤维化程度。大量研究表明,H_2S在肾脏纤维化过程中发挥保护作用,其机制包括抗炎症、抗氧化应激、抗上皮间质转化、调节细胞增殖与凋亡、抑制纤维母细胞活化等。As an endogenous gasotransmitter,hydrogen sulfide(H2S)is abundantly expressed in the kidney and plays an important regulatory role under different physiological and pathological conditions.In renal fibrosis,the level of H2S is significantly decreased,while supplement with exogenous H2S mitigates the severity of fibrosis.Many studies reveal that H2S plays a protective role in the development of renal fibrosis,and its mechanism includes anti inflammation,anti oxidation,inhibition of epithelial mesenchymal transition,regulation of cell proliferation and apoptosis,and inhibition of fibroblast activation.

关 键 词：硫化氢 肾脏 纤维化 氧化应激 表观遗传 

分 类 号：R692[医药卫生—泌尿科学]