姜黄素对猪圆环病毒灭活苗细胞免疫效果的影响  

ENHANCEMENT OF CURCUMIN ON IMMUNE RESPONSE OF INACTIVATED PORCINE CIRCONVIRUS TYPE 2 VACCINE IN PIGS

作　　者：余建国[1] 周立[1] YU Jian-guo;ZHOU Li(Jinhua Polytechnic, Zhejiang Province, Jinhua 321007, China)

机构地区：[1]浙江省金华职业技术学院,金华321007

出　　处：《中国动物传染病学报》2017年第5期60-63,共4页Chinese Journal of Animal Infectious Diseases

基　　金：浙江省公益科技项目(2011c22093)

摘　　要：为评价姜黄素对猪圆环病毒2型(Porcine circovirus type 2,PCV2)灭活疫苗在仔猪免疫效果中的作用,将60头三元杂交仔猪随机平均分成3组,Ⅰ组于14日龄注射PCV2灭活疫苗1头份+姜黄素0.5 m L,Ⅱ组于14日龄注射PCV2灭活疫苗1头份+姜黄素1 m L,对照组于14日龄接种PCV2灭活疫苗1头份。结果显示,Ⅰ组和Ⅱ组仔猪淋巴细胞转化率均高于对照组,差异具有显著统计学意义,外周血NK细胞数量和淋巴细胞数量也显著增加。结果表明PCV2灭活疫苗与姜黄素联合应用,可提高仔猪对PCV2的细胞免疫水平,且在一定剂量范围内,姜黄素浓度增加有利于免疫活性的增强。The purpose of this experiment was to evaluate the enhancement effect of curcumin on inactivated Porcine circovirus type2(PCV2)vaccine.Sixty piglets were randomly divided into3groups,20pigs each and immunized at14-days old.The piglets in group1were injected with one dose of PCV2vaccine plus0.5mL curcumin liquid,group2with one dose of PCV2vaccine plus1mL curcumin liquid and group3with one dose of PCV2vaccine only.Blood samples were collected and lymphocyte transformation was examined.The results showed significantly higher lymphocyte transformation in curcumin groups1and2than non-curcumin control group as evaluated from lymphocyte and NK cell counts.

关 键 词：姜黄素 PCV2 灭活疫苗 细胞免疫 仔猪 

分 类 号：R282.710.5[医药卫生—中药学]