加味二至丸联合外用米诺地尔酊治疗青年型男性脱发的临床观察  

Clinical observation on the efficacy of Two Solstices Pill Decoction plus Minoxidil Tincture for treating the male pattern alopecia

作　　者：张睿[1] ZHANG Rui(Department of Pharmacy,Shangluo Central Hospital,Shangluo,Shaanxi 726000,China)

机构地区：[1]商洛市中心医院药剂科,陕西商洛726000

出　　处：《安徽医药》2017年第12期2310-2314,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨加味二至丸联合外用米诺地尔酊对青年型男性脱发的疗效。方法选取男性型脱发患者126例,按随机数字表法分为三组,即西药组(米诺地尔酊外用)、中药组(加味二至丸)和联合治疗组(加味二至丸加米诺地尔酊外用),每组42例。超声仪检测三组患者治疗前后血流动力学特征变化;高分辨率扫描电子显微镜-X射线能谱仪测定秃发区微量元素Ca、Fe、Zn、Cu的含量;检测各组治疗后毛发生长速度、生长长度和毛囊状况,最后进行疗效判定。结果与治疗前相比,三组患者治疗后血流阻力指数(RI)明显下降,流速时间积分(VT_1)和峰值流速(V_(max))明显升高,且联合治疗组血流动力学改善效果较西药组和中药组明显(P<0.05);联合治疗组发中微量元素Fe、Ca、Zn、Cu含量明显升高,且升高幅度大于单纯西药和中药组(P<0.05);联合治疗组毛发生长速度为(12.605±3.271)×10^(-2) mm·d^(-1),治疗后总有效率高达92.9%,明显高于单纯中药组(76.2%)和西药组(54.8%),且联合治疗组毛囊生长期较另外两组延长(P<0.05)。结论加味二至丸联合外用米诺地尔酊对男性型脱发患者疗效确切,值得临床推广应用。Objective To investigate the efficacy of two solstices pill decoction plus minoxidil tincture for treating the male pattern alopecia.MethodsData of126cases with male pattern alopecia were collected.All patients were randomly assigned into three groups,the western medicine group(minoxidil tincture,n=42),Chinese medicine group(two solstices pill decoction,n=42)and the combining treatment group(two solstices pill decoction plus topical minoxidil tincture,n=42).We detected the change of hemodynamic characteristics for three groups pre treatment and posttreatment.The content of trace elements(Ca,Fe,Zn,Cu)of alopecia area were determined by high resolution scanning electron microscope and X rays.Then we detected the growth rate of hair and hair follicle length growth,and evaluated the efficacy of the treatment.ResultsCompared with pre treatment,RI decreased significantly after treatment,VT1and Vmax increased significantly in three groups,and the hemodynamic change in combining treatment group was more obvious than that in western medicine group and Chinese medicine group(P<0.05).The content of trace elements(Ca,Fe,Zn,Cu)of alopecia area in combining treatment group increased significantly greater than that in western medicine or Chinese medicine group(P<0.05).The hair growth rate was(12.605±3.271)×10-2mm·d-1after treatment and the total effective rate was up to92.9%in combining treatment group,which were significantly higher than the Chinese medicine(76.2%)and western medicine treatment group(54.8%,P<0.05).ConclusionsTwo solstices pill decoction plus minoxidil tincture has good effect in the treatment of patients with male pattern alopecia,which was worthy of clinical application.

关 键 词：加味二至丸 米诺地尔酊 男性脱发 微量元素 血流动力学 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]