帕瑞昔布钠超前镇痛在剖宫产术中应用对应激指标影响的临床分析  

Clinical analysis of the effect of preemptive analgesia with parecoxib sodium on the corresponding index in cesarean section

作　　者：于明[1] 赵立福[1] 方略[1] 雷宇[1] YU Ming;ZHAO Li fu;FANG Lue;LEI Yu(Department of Anesthesiology, Guangyuan Central Hospital, Guangyuan City, Sichuan Province 628000, China)

机构地区：[1]四川省广元市中心医院麻醉科,四川广元628000

出　　处：《海南医学院学报》2017年第17期2381-2383,2387,共4页Journal of Hainan Medical University

基　　金：四川省科技厅科研项目(1612317)~~

摘　　要：目的:探讨帕瑞昔布钠超前镇痛在剖宫产术中应用对产妇炎性因子、P物质和应激指标的影响。方法:选取我院需行剖宫产术产妇84例,按入院时间分为2组,每组42例,设置为观察组和对照组,观察组于麻醉诱导前30 min予以帕瑞昔布钠,对照组则予以生理盐水,分别于手术前、手术结束后30min、术后4h、术后8h和术后12h采集静脉血进行化验,比较两组手术前、后的炎性因子、P物质和应激指标。结果:两组患者P物质均于手术结束后30min开始升高,于术后4h达到高峰值,随后逐渐下降,而E(肾上腺素)和NE(去甲肾上腺素)于手术结束后30min即达到高峰值,随后逐渐下降,且观察组手术结束后30min、术后4h、术后8h和术后12h的P物质指标、E和NE指标低于对照组相同时间点,差异均具有统计学意义(P<0.05)。结论:帕瑞昔布钠超前镇痛在剖宫产术中应用临床效果较好,可有效降低炎症反应,缓解疼痛,减轻应激反应,促进术后恢复,推荐临床广泛应用。Objective:To explore the application of parecoxib preemptive analgesia effect on maternal inflammatory factor,substance P and the stress index in cesarean section.Methods:A total of84cases who received cesarean section in our hospital were selected,and divided into the observation group and the control group with42cases each according to their admission time.The observation group received parecoxib sodium30min before anesthesia induction,and control group was given normal saline,respectively.The venous blood samples were collected before operation,30min,4h,8h and12h after operation respectively.The inflammatory factors,P substances and stress indexes were compared between the two groups before and after operation.Results:Substance P in the two groups increased30min after operation,and reached a high peak4h after operation,and then decreased gradually,while E(epinephrine)and NE(norepinephrine)reached peak values30min after operation and then decreased gradually.P substances,E(epinephrine)and NE(norepinephrine)in observation group were lower than those of control group30min,4h,8h and12h after operation,and the difference was statistically significant(P<0.05).Conclusion:The clinical effect of parecoxib sodium preemptive analgesia in cesarean section is better.It can effectively reduce inflammatory reaction,relieve pain,relieve stress reaction,and promote postoperative recovery,it is recommended to be widely used in clinic.

关 键 词：帕瑞昔布钠 超前镇痛 剖宫产 炎性因子 P物质 应激指标 

分 类 号：R719.8[医药卫生—妇产科学]