激光扫描共聚焦显微镜在纳米毒理学研究中的应用  

Applications of confocal microscope in nanotoxicology research

作　　者：吴安庆[1] 马晓川 WU An-qing;MA Xiao-chuan(School of Radiation Medicine and Protection,Soochow University, Suzhou Jiangsu 215123, China)

机构地区：[1]苏州大学放射医学与防护学院,江苏苏州215123

出　　处：《电子显微学报》2017年第5期517-521,共5页Journal of Chinese Electron Microscopy Society

基　　金：中国博士后第59批面上资助项目(No.7131705016)

摘　　要：随着激光扫描共聚焦显微镜技术的不断更新,功能不断拓展,已成为新兴学科纳米毒理学及其交叉学科科学研究的重要工具。激光扫描共聚焦显微镜能够动态检测纳米颗粒在活细胞内的定位及其与细胞骨架、细胞内离子、生物大分子的相互作用,有助于深入研究纳米颗粒对机体的毒理学效应及其机制。With the continuous updating of laser confocal microscope and the expansion of its function,it has become an important instrument for nanotoxicology and its interdisciplinary scientific research.It can observe the localization of nanoparticles in cells and its interaction with cytoskeleton,intracellular ions and biological molecules,which is helpful to study the toxicological effects and mechanism of nanoparticles on the organism.

关 键 词：激光扫描共聚焦显微镜 纳米毒理学 纳米颗粒 细胞成 

分 类 号：R994.2[医药卫生—毒理学]