单纯低甲状腺素血症与不良妊娠结局关系的Meta分析  

A Meta Analysis of Relationships between Isolated Hypothroxinemia and Pregnancy Outcomes

作　　者：岳欣欣[1] 傅全威[2] 付洋[2] YUE Xinxin;FU Quanwei;FU Yang(Teaching and Research Department of Internal Medicine,HE's Medical University,Shenyang 110840,China)

机构地区：[1]辽宁何氏医学院内科学教研室,沈阳110163 [2]沈阳军区总医院医疗科

出　　处：《解放军预防医学杂志》2017年第9期1098-1102,共5页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：辽宁省科技攻关课题(No.2012225110)

摘　　要：目的系统评价妊娠期妇女单纯低甲状腺素血症与不良妊娠结局的相关性。方法计算机检索Pubmed、Embase、中国生物医学文献数据库、维普中文科技期刊数据库、万方数据库和中国知网,收集妊娠期妇女单纯低甲状腺素血症与不良妊娠结局的队列研究,两位研究者独立筛选及纳入文献,提取相关资料及数据,采用Review Manager 5.1软件进行Meta分析。结果共纳入8篇文献进行研究,结果显示孕期单纯低甲状腺素血症与胎盘早剥具有相关性[OR=1.97,95%CI(1.06,3.66)]。结论孕期单纯低甲状腺素血症可能会增加胎盘早剥的风险。Objective To systematically evaluate the relationships between isolated hypothroxinemia and pregnancy outcomes.Methods We electronically searched CNKI,VIP,WanFang Data,PubMed and EMbase databases to collect cohort studies on the association between isolated hypothroxinaemia and pregnancy outcomes.Two reviewers independently screened literature according to the inclusion and exclusion criteria before meta-analysis was performed using Review Manager5.1software.Results A total of8studies were included in the meta-analysis.The results of meta-analysis showed that isolated hypothroxinaemia during pregnancy was associated with increased risks of placental abruption〔OR=197,95%CI(106,366)〕.Conclusion Isolated hypothroxinaemia during pregnancy may increase the risk of placental abrupton.

关 键 词：单纯低甲状腺素血症 妊娠结局 META分析 队列研究 

分 类 号：R714.256[医药卫生—妇产科学]