基质细胞衍生因子1/CXC族细胞因子受体4信号轴对大鼠牙齿移动速率的影响  

Role of stromal cell-derived factor 1/CXC chemokine receptor axis in rat tooth movement

作　　者：程钎 林富伟 谢乙加 黄跃 王军[2] Cheng Qian;Lin Fu-wei;Xie Yi-jia;Huang Yue;Wang Jun(Department of Orthodontics, Stomatological Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China;Department of Orthodontics,Hospital of Stomatology of West China School, Sichuan University, Chengdu 610000, Sichuan Province, China)

机构地区：[1]西南医科大学附属口腔医院正畸科,四川省泸州市646000 [2]四川大学华西口腔医学院正畸科,四川省成都市610000

出　　处：《中国组织工程研究》2017年第36期5757-5762,共6页Chinese Journal of Tissue Engineering Research

基　　金：泸州医学院青年基金(2014QN-050)~~

摘　　要：背景:正畸治疗的疗程长,复诊间隔时间过长,一直是困扰正畸临床医师及患者的一个重要问题,如何加快正畸牙移动是目前研究的难点。目的:验证能否通过局部注射CXC族细胞因子受体4抑制剂AMD3100获得加速牙移动速率的效果,探索基质细胞衍生因子1/CXC族细胞因子受体信号轴在牙移动的作用。方法:选择8-10周龄的大鼠90只,构建正畸牙移动动物模型。将实验分为3组,分别注射基质细胞衍生因子1、CXC族细胞因子受体4抑制剂AMD3100、PBS,均在观察1,3,5,7,10,14 d时分批处死,测量牙移动距离。结果与结论:(1)分析测量显示基质细胞衍生因子1组、AMD3100组与PBS组之间牙移动距离有差别,CXC族细胞因子受体4抑制剂AMD3100可在一定程度上加速正畸牙齿的移动,而基质细胞衍生因子1则表现出对牙移动的抑制作用;(2)实验初步证实了基质细胞衍生因子1/CXC族细胞因子受体信号轴在正畸牙移动中的重要作用。BACKGROUND:Orthodontic treatment has a long course and referral interval,which is an important difficulty.How to accelerate orthodontic tooth movement is an issue of concern.OBJECTIVE:To testify whether the local injection of AMD3100(CXCR4antagonist)can accelerate the tooth movement or not,and to explore the role of stromal cell-derived factor1/CXC chemokine receptor axis in tooth movement.METHODS:Ninety Sprague-Dawley rats aged8-10weeks old were selected and the models of orthodontic tooth movement were established.The model rats were randomized into three groups,and then given the injection of stromal cell-derived factor1,AMD3100or PBS.The rats were killed at1,3,5,7,10and14days to measure the tooth movement distance.RESULTS AND CONCLUSION:The tooth movement distance showed difference among three groups;AMD3100could facilitate the tooth movement,while stromal cell-derived factor1exerted inhibitory effect on the tooth movement.To conclude,stromal cell-derived factor1/CXC chemokine receptor axis plays an important role in tooth movement.

关 键 词：组织构建 骨组织工程 正畸牙移动 基质细胞衍生因子1 CXCR4 AMD3100 

分 类 号：R318[医药卫生—生物医学工程]