骨组织血管系统中血管形成与骨形成的偶联效应  

Coupling of osteogenesis and angiogenesis in bones

作　　者：杨瑾廷 韩向龙[1] Yang Jin-ting;Han Xiang-long(State Key Laboratory for Oral Diseases, Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China)

机构地区：[1]口腔疾病研究国家重点实验室,四川大学华西口腔医院正畸科,四川省成都市610041

出　　处：《中国组织工程研究》2017年第36期5855-5861,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81371172,81671024)~~

摘　　要：背景:骨组织中的血管系统除了是运载氧气、营养、代谢废物的管道系统以外,还调控着骨形成的多个方面,并为骨髓内造血干细胞提供细胞来源。在骨发育、骨成熟、骨老化和骨疾病的发生和发展中,血管形成和骨形成偶联,起着十分重要作用。目的:对骨组织中血管构成及形成过程及影响骨血管的相关因素作一综述。方法:电子检索CBM和Pub Med数据库,中英文检索词分别为"骨形成;血管系统;血管形成"和"osteogenesis;blood vasculature;angiogenesis"。选择性地纳入有关骨组织血管系统和血管形成的高质量文献,排除重复发表文献。共纳入65篇文献,探讨二者间的偶联关系。结果与结论:(1)骨骼系统的形成和稳定依靠几种不同类型的细胞活性的相互协调,尤其是内皮细胞作为信号的重要来源,调控软骨细胞和成骨相关细胞,因而使得在发育和再生中血管形成和骨形成发生偶联;(2)和其他器官一样,骨组织中的血管系统表现出典型的层次结构,动脉干分支流入广泛的毛细血管网,然后汇入骨干中心的大静脉;(3)影响骨血管形成的因素主要有血管内皮生长因子、成纤维细胞生长因子2、血小板衍化生长因子、基质金属蛋白酶、低氧状态、Notch信号通路等;(4)血管形成和骨形成的偶联作用提示,调控骨形成和调控血管形成的某一过程或相关细胞分子,将可能为未来治疗骨质疏松、骨肿瘤、骨折修复、骨再生提供新的思路和治疗手段。BACKGROUND:In addition to a conduit system for oxygen,nutrients and waste products,blood vessels in bones manipulate multiple aspects of bone formation and provide niches for bone marrow hematopoietic stem cells.Coupling of osteogenesis and angiogenesis plays a crucial role in bone development,maturation,ageing and diseases.OBJECTIVE:To review the architecture of bone vasculature and process of angiogenesis,and then discuss the factors regulating coupling of osteogenesis and angiogenesis.METHODS:CBM and PubMed databases were retrieved using the keywords of“osteogenesis,blood vasculature,angiogenesis”in Chinese and English,respectively.High-quality articles related to the blood vasculature and angiogenesis in bones were included,and the repetitive studies were excluded.Finally65eligible articles were included to explore the coupling of osteogenesis and angiogenesis.RESULTS AND CONCLUSION:The formation and stabilization of the skeletal system rely on the coordination of several different types of cellular activities,especially endothelial cells as an important source of signals that regulate chondrocytes and osteogenesis-related cells,thus allowing the coupling of angiogenesis and osteogenesis during development and regeneration.Like other organs,the vascular system in the bones exhibits a typical hierarchy;the arterial trunk branches flow into the capillary network and then converge into the large veins in the center of the bone.Vascular endothelial growth factor,fibroblast growth factor2,platelet-derived growth factor,matrix metalloproteinases,hypoxia,and Notch signaling pathway are involved in the angiogenesis in bones.The signaling pathways and related cytokines regulating the coupling of osteogenesis and angiogenesis will provide a new treatment strategy to battle bone diseases such as osteoporosis,bone tumor,bone fracture and bone repair.

关 键 词：组织构建 骨组织工程 骨形成 血管系统 血管形成 内皮细胞 软骨细胞 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]