下呼吸道感染患者痰标本中产ESBLs菌株的分布及耐药情况  

Distribution and drug resistant status of bacterium extended spectrum beta lactamases in sputum samples from patients with lower respiratory tract infection

作　　者：罗世容 唐卫东 谭旭斌 冯涛 杨璐萍[1] 周丽[1] LUO Shirong;TANG Weidong;TAN Xubin;FENG Tao;YANG Luping;ZHOU Li(Department of Clinical Laboratory,Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine,Panzhihua,Sichuan 617000,China)

机构地区：[1]攀枝花市中西医结合医院检验科,四川攀枝花617000

出　　处：《国际检验医学杂志》2017年第20期2835-2836,2839,共3页International Journal of Laboratory Medicine

摘　　要：目的研究该院下呼吸道感染患者痰标本中产超广谱β-内酰胺酶(ESBLs)菌株的分布及耐药情况,为合理使用抗菌药物提供依据。方法收集2014年1月至2016年1月该院下呼吸道感染患者的痰标本中分离出的革兰阴性杆菌512株,采用标准纸片扩散法对ESBLs进行检测,采用K-B纸片扩散法检测药敏,分析革兰阴性杆菌中产ESBLs菌的分布及耐药情况。结果干部病房和ICU中,产ESBLs菌分离率高于呼吸科病房,且差异有统计学意义(P<0.01)。呼吸科、干部病房及ICU分离的产ESBLs菌均以大肠埃希菌和阴沟肠杆菌为主。分离的产ESBLs革兰阴性菌对甲氧苄啶的耐药率最低。结论掌握下呼吸道感染患者的病原菌分布及耐药情况,有利于辅助临床医师合理用药。ObjectiveTo study the distribution of bacterium extended spectrum beta lactamases(ESBLs)in sputum samples from patients with lower respiratory tract infection in Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine.MethodsA total of512strains of gram negative bacterium were isolated from sputum samples of patients with lower respiratory tract infection from January2014to January2016,standard disk diffusion method was used to detected ESBLs,drug sensitivity was performed by K B disk diffusion method.Distribution and drug resistant status of ESBLs bacterium were analyzed.ResultsDetection rate of ESBLs bacteriumin cadre ward and ICU were higher than that in department of respiration,and the difference was statistical significant(P<0.01).Among ESBLs bacterium isolated from department of respiration,Escherichia coli accounted for37.5%,Enterobacter cloacae accounted for25.8%.Among ESBLs bacterium isolated from cadre ward,Escherichia coli accounted for58.2%,Enterobacter cloacae accounted for45.5%.The resistant rate of gram negative bacterium producing ESBLs to trimethoprim was lowest.ConclusionIt′s important to understand the distribution and drug resistant status of gram negative bacterium,so as to provide the basis for rational use of antibiotics.

关 键 词：下呼吸道 超广谱Β内酰胺酶 耐药性 分布 

分 类 号：R446.5[医药卫生—诊断学] R56[医药卫生—临床医学]