比伐芦定、替罗非班应用于急性心肌梗死患者经皮冠状动脉介入治疗的效果和安全性  

Effect and safety of bivalirudin and tirofiban using in patients with acute myocardial infarction during percutaneous coronary intervention

作　　者：罗巍[1] 周海依[2] LUO Wei;ZHOU Hai-yi(Department of Cardiology,Hunan Province People′s Hospital,Changsha 410000,China;Department of Zone 1 Thorax,Changsha Central Hospital,Changsha 410000,China)

机构地区：[1]湖南省人民医院心血管内科,长沙410000 [2]长沙市中心医院胸一科,长沙410000

出　　处：《岭南心血管病杂志》2017年第6期665-668,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨在急性心肌梗死患者经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗中应用比伐芦定、替罗非班的效果及安全性。方法选择2015年3月至2016年6月期间在湖南省人民医院接受PCI治疗的68例急性心肌梗死患者为研究对象。患者的按随机数字表法分为数量相等的两组。在PCI治疗中,对照组应用替罗非班,观察组应用比伐芦定,观察并比较两组PCI成功率及氨基末端脑钠肽前体(N-terminalpro-brain natriuretic peptide,NT-pro BNP)浓度。结果两组PCI治疗成功率均为100%,组间比较差异无统计学意义(P>0.05);PCI治疗后,两组NT-proBNP浓度均有明显提高,与治疗前比较差异均有统计学意义(P<0.05);但两组治疗后NT-porBNP浓度比较,差异无统计学意义(P>0.05)。观察组轻度出血事件发生率为5.88%,明显低于对照组的23.53%,差异有统计学意义(P<0.05);两组均无患者出现严重出血。结论在急性心肌梗死患者接受PCI治疗过程中,应用比伐芦定和替罗非班均可取得良好的效果,但是比伐芦定的应用安全性更高。Objectives To discusses the effect and safety of bivalirudin and tirofiban using in patients with acute myo?cardial infarction(AMI)during percutaneous coronary intervention(PCI).Methods Totally68patients with AMI received PCI were selected from March2015to June2016in Hunan Province People′s Hospital.They were randomly divided into equal number of two groups:patients in control group received tirofiban and patients in observation group received bivalirudin during PCI.Success rate of PCI and plasma concentration of N-terminal pro-brain natriuretic pep?tide(NT-proBNP)were compared between the two groups.Results Success rates of PCI in the2groups were100%,and there was no significant difference between the two groups(P>0.05).After treatment,plasma concentrations of NT-porBNP in the two groups significantly increased when compared with those before treatment(P<0.05),but there was no significant difference between the two groups(P>0.05).Incidence of mild bleeding events was5.88%in obser?vation group,which was significantly lower than that of control group(23.53%)(P<0.05).There were no patients with severe bleeding in the two groups.Conclusions In patients with AMI treated by PCI,application of bivalirudin and tirofiban both can achieve good effect,but bivalirudin can get higher security.

关 键 词：心肌梗死 血管成形术 经腔 经皮冠状动脉 替罗非班 比伐芦定 

分 类 号：R542.22[医药卫生—心血管疾病]