面向临床应用的光声成像技术  

Photoacoustic Imaging Technology for Clinical Applications

作　　者：朱? LIN Riqiang;LENG Ji;CHEN Jingqin;LIU Chengbo;GONG Xiaojing;SONG Liang(Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen Guangdong 518055, China;Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Guangdong 518055, China)

机构地区：[1]武汉光电国家实验室,广东深圳518060 [2]生物医学光子学教育部重点实验室

出　　处：《中国医疗设备》2018年第1期1-5,15,共6页China Medical Devices

基　　金：国家自然科学基金(61475182,81522024,81427804);广东省科技计划(2014B050505013);深圳市基础研究计划(YJ20150521144321005,JCYJ20150401145529037,JCYJ20150731154850923,JCYJ20160608214524052,JCYJ20160531175040976,JCYJ20170413153129570);中科院优秀青年基金(2017048)

摘　　要：编者按:光与生物体的作用包含着丰富的信息,从组织对光的吸收、散射、偏振、到光的发射,在此基础上发展起来的生物医学光子学成像技术以高灵敏、非侵入性的特点,在基础医学研究与临床诊断方向发挥着重要作用。为克服光学本身在穿透深度的局限性,光学与其它模态的结合更是为高分辨获取深层组织的信息带来新契机。本栏目遴选几篇有关生物医学光子学成像与诊断领域研究、开发的新进展,涉及组织表面的荧光诊断、到微血管网的结构与功能成像。相比于生物医学光学成像技术的广泛性而言,这几篇文章只是冰山一角,但也不失为一个好的开端。Photoacoustic imaging is a novel imaging modality that utilizes pulsed laser to illuminate samples and ultrasonic transducers for detection of the laser absorption generated ultrasonic/photoacoustic waves.Benefited from its high optical contrast and acoustic resolution at depth,as well as the capability of acquiring optical spectral information,photoacoustic imaging allows for structural and functional imaging of the biological relevant information such as hemoglobin concentration,blood oxygen metabolism,and lipid with high specificity,and is able to capture the corresponding physiological feature dynamics with high sensitivity.In terms of the imaging system,photoacoustic imaging manifests a variety of embodiments catering the multi-scale biomedical imaging needs.The above mentioned features and capabilities enable extensive biomedical application potentials of this imaging modality in both clinical diagnosis and pathological analysis,such as malignant tumor detection,atherosclerotic plaque assessment,and microcirculation abnormality diagnosis.Therefore,it is attracting more and more attention and interests in a wide range of biomedical research areas.This article presented the recent progress of photoacoustic technology development and application studies in our group in the fields of microvascular imaging,intravascular imaging,gastrointestinal endoscopic imaging,and sentinel lymph node imaging.

关 键 词：光声成像 临床应用 光学分辨率 血管内成像 消化道内窥成像 前哨淋巴结成像 

分 类 号：Q-334[生物学]