2016年某院超药品说明书用药分析  

Analysis of Off-Label Uses in 2016 in a Hospital

作　　者：冯桂梅[1] 王曙光[1] Feng Guimei;Wang Shuguang(Department of Pharmacy, Hunan Aerospace Hospital, Changsha, Hunan, China 410205)

机构地区：[1]湖南航天医院药剂科,湖南长沙410205

出　　处：《中国药业》2017年第24期68-70,共3页China Pharmaceuticals

基　　金：湖南省长沙市科技计划项目[kq1602021]

摘　　要：目的了解医院门诊及住院患者超药品说明书用药情况。方法分层随机抽取医院2016年全年门诊处方及住院医嘱,参照药品说明书及相关内容,统计并分析超说明书用药情况。结果共收集用药记录7 387条,超说明书用药169项,涉及药品47个;超说明书用药中药品种类主要集中在抗菌药物(39项,23.08%),中药注射剂(31项,18.34%),抗变态反应药(24项,14.20%);给药剂量(56项,33.14%),给药频次(38项,22.49%),适应证(31项,18.34%),给药途径(25项,14.70%)超说明书用药占比近90.00%;美罗培南(31项,18.34%),头孢哌酮舒巴坦(20项,11.83%),奥美拉唑肠溶片(14项,8.28%)为该院2016年超说明书用药率排名前3位的药品;超说明书用药的风险最高人群为儿童(2~11岁),女性高于男性,中级和初级职称医师超说明书用药的风险均相对较高,差异有统计学意义(P<0.05)。结论超说明书用药情况在该院普遍存在,要建立健全超说明书用药管理制度,以保障患者用药安全,需要药品生产、监管、使用等各环节工作者共同努力。To understand the situation of off-label uses of the outpatient and inpatients in our hospital.Methods The out patientprescriptions and hospitalization orders in2016were stratified and randomly selected,and the situation of the medication of the super instructions was analyzed according to the drug instructions and related contents.Results A total of169off-label uses with7387medication administration records were sampled,and47kinds of drugs were involved.The off-label drug use of medicines were mainly in antibiotics(39cases,23.08%),Chinese medicine injectio(31cases,18.34%),antiallergic drugs(24cases,14.20%);drug dosage(56cases,33.14%),the frequency of administration(38cases,22.49%),indications(31cases,18.34%),route of administration(25cases,14.7%),the off-label uses accounted for more than90.00%.Meropenem(31cases,18.34%),cefoperazone sulbactam(20cases,11.83%),Omeprazole Enteric-coated Tablets(14cases,8.28%)were the top3drugs with highest component ratios of the total off-label uses.The children(2-11years old)might have higher risk factors of off-label uses,and female patients were more than male patients,the incidence rate and risk of off-label uses of the prescriptions prescribed by doctors with intermediate and primary professional titles were significantly higher than those with vice senior and senior professional title(P<0.05).Conclusion The off-label uses of outpatient prescriptions and hospitalization orders is common in the hospital.It is necessary to establish and improve the management system for off-label uses,so as to ensure the safety of patients'medication,which needs the collective efforts of workers in pharmaceutical production,supervision and use

关 键 词：超说明书用药 用药安全 合理用药 

分 类 号：R969.3[医药卫生—药理学] R952[医药卫生—药学]