斑马鱼肠道微生物的研究进展  

Research progress on intestinal tract microorganisms in zebrafish

作　　者：张金花 桂芳 司婧[1] 张红[1,4] 周蓉 甘露[1] ZHANG Jin-hua;GUI Fang;SI Jing;ZHANG Hong;ZHOU Rong;GAN Lu(Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou730000, China;University of Chinese Academy of Sciences, Beijing100049;Lanzhou Urban Water Supply (Group) Co. , Ltd, Lanzhou730000;Wuwei Cancer Hospital, Gansu Wuwei733000)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]中国科学院大学,北京100049 [3]兰州城市供水(集团)有限公司,兰州730000 [4]武威肿瘤医院,甘肃武威733000

出　　处：《中国实验动物学报》2017年第6期637-642,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金联合基金重点项目(No.U1432248);国家自然科学基金青年科学基金(No.11605255);科技部国家重点研发项目(No.2016YFC0904600);兰州市科技计划项目(2015-3-75)

摘　　要：肠道微生物作为人体重要的"微生物器官",在人体发育、肠道屏障、免疫调节、营养物质消化吸收、毒素排出、血管生成,以及疾病的发生、发展等方面发挥着巨大的作用。脊椎动物生物模型斑马鱼因其各系统发育与人类相应系统有许多共同特点,且具有胚胎透明、发育快速、肠道易于取样等优势,故成为研究肠道微生物的理想模型。然而在国内关于斑马鱼肠道微生物的研究尚处于起步阶段。文章总结了斑马鱼中肠道微生物的相关功能、肠道微生物群落的构建及其演替规律及肠道微生物结构的影响因素,为研究肠道微生物对人类健康的影响及其在疾病治疗中的应用前景提供理论依据。Intestinal microbiota as an important“microbial organ”in the human body may play a key role in the human development,intestinal barrier,immune regulation,digestion and nutrient absorption,detoxification,angiogenesis,as well as the occurrence and development of diseases.As a vertebrate biotype,zebrafish is widely used in the fields of developmental biology,immunology,genetics,toxicology and the establishment of human disease models,because of their common development and phylogenetic system with humans.A number of unique features,including its transparent embryos,rapid development,easy to take intestinal samples,and other advantages,made its wide popularity as an ideal model for the study of intestinal microbes.However,the research on zebrafish intestinal microbiology is still at an elementary stage.This paper summarizes the recent progress in research of zebrafish intestinal microbiota,including the related function of intestinal microbes in zebrafish,the assembly and succession of intestinal microbial community and factors influencing the intestinal microbial structure,and provides a theoretical basis for studying the effects of intestinal microbes on human health and its application in the treatment of diseases.

关 键 词：肠道微生物 斑马鱼 相关功能 演替规律 影响因素 人类健康 

分 类 号：Q95-33[生物学—动物学]