抑郁症肠道微生物组紊乱假说的现状与展望  

Hypothesis and prospects of disturbed gut microbiota in major depressive disorder

作　　者：叶飞 郑鹏[1,2] 谢鹏 YE Fei;ZHENG Peng;XIE Peng(Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing400016,China;Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing400016)

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016 [2]重庆医科大学神经科学及脑科学协同创新中心,重庆400016

出　　处：《中国实验动物学报》2017年第6期654-657,共4页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家重点研发计划重大慢性非传染性疾病重点专项(No.2016YFC1307200);国家自然科学基金(No.81771490)资助

摘　　要：抑郁症是一种基因与环境交互影响的重大精神疾病。其发病机制学说众多,但仍未获得广泛认同。肠道微生物是人体最大、最直接的外环境,已成为解析抑郁症的全新切入点。根据最新研究进展,本文将从以下几个方面来进行综述:(1)肠道微生物通过"微生物-肠-脑"轴影响脑神经生化和行为表型;(2)肠道微生物紊乱与抑郁发生的相关性;(3)肠道微生物在抑郁发生中的潜在致病机制;(4)展望以抑郁症肠道微生物紊乱为靶点,开发抑郁症新的诊治方法。Major depressive disorder(MDD)is one of the severe mental illness caused by genetic and environmental interactions.There are several hypotheses that sought to account for this disorder.However,none of them is widely recognized.Gut microbiome,the largest and most direct external environment for human body,is considered as a new focus in the research of MDD.Based on the new development,we will summarize the following aspects of MDD in this article:(1)How the gut microbiome shapes the brain neurochemistry and behaviors through microbiota gut brain axis?(2)Association between disturbances of gut microbiome and MDD;(3)The potential pathogenesis of gut microbiome in the onset of MDD;(4)The prospects of developing new diagnosis and treatment for MDD by targeting microbiota gut brain axis.

关 键 词：抑郁症 肠道微生物组 微生物-肠-脑轴 

分 类 号：Q95-33[生物学—动物学]