新生儿坏死性小肠结肠炎动物模型研究进展  

Progress in research on animal models of neonatal necrotizing enterocolitis

作　　者：杨凯蒂 贺雨[1,2,3,4] 曾本华 肖洒[1,2,3,4] 艾青[1,2,3,4] 魏泓 余加林[1,6,2,3,4] YANG Kai-di;HE Yu;ZENG Ben-hua;XIAO Sa1;AI Qing;WEI Hong;YU Jia-lin(Department of Neonatology, Children’s Hospital of Chongqing Medical University, Chongqing400014, China;Shenzhen University General Hospital, Shenzhen518055;Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing400014;China International Science and Technology Cooperation Base of Immunity, Chongqing400014;Chongqing Key Laboratory of Child Infection and Immunity, Chongqing400014;Department of Laboratory Animal Science, College of Basic Medicine,Medical University, Chongqing400038)

机构地区：[1]重庆医科大学附属儿童医院新生儿中心,重庆400014 [2]儿童发育疾病研究教育部重点实验室,重庆400014 [3]儿童发育重大疾病国家国际科技合作基地,重庆400014 [4]儿科学重庆重点实验室,重庆410014 [5]第三军医大学基础部实验动物学教研室,重庆400038 [6]深圳大学总医院儿科,深圳518055

出　　处：《中国实验动物学报》2017年第6期689-692,共4页Acta Laboratorium Animalis Scientia Sinica

摘　　要：新生儿坏死性小肠结肠炎(NEC)是新生儿时期严重的胃肠道疾病,病死率高,多见于早产儿,极低出生体重儿,但确切病因及发病机制尚未阐明。积极探寻其发病机制,需建立可靠的动物模型以助于对该病的病因、发病机制及防治等各方面进行深入研究,以改善NEC患儿预后有重要意义。Neonatal necrotizing enterocolitis(NEC)is a severe gastrointestinal disease with high mortality.Studies have suggested that NEC are associated with prematurity and very low birth weight,but the exact etiology and pathogenesis has not been elucidated.Therefore,it is important to build an ideal NEC model to explore the pathogenesis and prevention measures of NEC to reduce the incidence and severity of NEC.

关 键 词：坏死性小肠结肠炎 动物模型 新生儿 

分 类 号：Q95-33[生物学—动物学]