维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响  

Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis

作　　者：李益明[1] 张玲[1] 邢小珍 王志芳[1] 祝亮[1] 顾海珍 鲁庆红 姜金孝 LI Yi-ming;ZHANG Ling;XING Xiao-zhen;WANG Zhi-fang;ZHU Liang;GU Hai-zhen;LU Qing-hong;JIANG Jin-xiao(Nephrology Department, Huanggang Central Hospital in Hubei Province, Huanggang City, Hubei Province, 438000, China)

机构地区：[1]湖北省黄冈市中心医院肾病学科,湖北黄冈438000

出　　处：《海南医学院学报》2017年第19期2635-2637,2641,共4页Journal of Hainan Medical University

基　　金：长江大学黄冈临床医学院(WJ2016-YZ-44)~~

摘　　要：目的:探讨维生素C联合维生素E对血液透析患者抗氧化力、炎症反应状态的影响。方法:收集在本院接受血液透析治疗的尿毒症患者116例,随机分为对照组及观察组各58例。对照组接受维生素C干预、观察组接受维生素C联合维生素E干预。对比两组干预前及干预后6周时血清中抗氧化指标、促炎介质、抗炎介质含量的差异。结果:干预前,两组血清中抗氧化指标、促炎介质、抗炎介质含量的差异不显著。干预后,两组血清中SOD、GSH-PX、T-AOC的含量均高于治疗前,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于治疗前且观察组患者血清中SOD、GSH-PX、T-AOC的含量均高于对照组,IL-1、IL-2、IL-6、IL-8、IL-4、IL-10、IL-13的含量均低于对照组。结论:血液透析患者接受维生素C联合维生素E干预,可有效增强机体的抗氧化力并抑制全身炎症状态。Objective:To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis.Methods:116patients with uremia who received hemodialysis in the hospital between December2014and January2017were collected and divided into control group and observation group by random number table,each with58cases.Control group received vitamin C intervention,and observation group received vitamin C combined with vitamin E intervention.The differences in serum levels of antioxidant indexes,pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and6weeks after intervention.Results:Before intervention,serum levels of antioxidant indexes,pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups.After intervention,serum SOD,GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1,IL-2,IL-6,IL-8,IL-4,IL-10and IL-13levels were lower than those before treatment,and serum SOD,GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1,IL-2,IL-6,IL-8,IL-4,IL-10and IL-13levels were lower than those of control group.Conclusion:Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.

关 键 词：血液透析 维生素C 维生素E 抗氧化力 炎症反应 

分 类 号：R692.5[医药卫生—泌尿科学]