瑞舒伐他汀强化治疗对ACS患者PCI术后血脂代谢、脂肪细胞因子、斑块稳定性的影响  

Effect of rosuvastatin intensification therapy on blood lipid metabolism,adipocytokines and plaque stability after PCI in ACS patients

作　　者：孙秀全[1] 李彦芳 孟英杰[1] 石桂芳 SUN Xiu-quan;LI Yan-fang;MENG Ying-jie;SHI Gui-fang(Cardiology Department No. 2, Jizhong Energy Fengfeng Group Hospital in Fengfeng District in Hebei Province, Handan City, Hebei Province, 056200, China)

机构地区：[1]河北邯郸峰峰矿区冀中能源峰峰集团总医院心内二科,河北邯郸056200

出　　处：《海南医学院学报》2017年第19期2652-2655,共4页Journal of Hainan Medical University

基　　金：邯郸市科学技术研究与发展计划项目资助(1623208102ZC)~~

摘　　要：目的:探讨瑞舒伐他汀强化治疗对ACS患者PCI术后血脂代谢、脂肪细胞因子、斑块稳定性的影响。方法:选择在本院接受PCI治疗的106例ACS患者,回顾治疗方案并分为接受PCI术后瑞舒伐他汀常规剂量治疗的常规剂量组60例、接受PCI术后瑞舒伐他汀强化治疗的强化治疗组46例。对比两组患者治疗前后血脂代谢、脂肪细胞因子、斑块稳定性的差异。结果:PCI术前,两组患者的血脂代谢、脂肪细胞因子、斑块稳定性差异无统计学意义(P>0.05);PCI术后1月,强化治疗组患者外周血中脂质代谢指标HDL-C、ApoA1的含量高于常规剂量组,LDL-C、ApoB的含量低于常规剂量组;血清中脂肪细胞因子APN、Leptin的含量高于常规剂量组,Resistin的含量低于常规剂量组;斑块稳定性相关指标ICAM-1、MMP-1、TIMP-1的含量低于常规剂量组(P<0.05)。结论:ACS患者PCI术后接受瑞舒伐他汀强化治疗,可有效调节机体脂质代谢并增加斑块稳定性。Objective:To explore the effect of rosuvastatin intensification therapy on blood lipid metabolism,adipocytokines and plaque stability after PCI in ACS patients.Methods:ACS patients who received PCI in the hospital between July2015and January2017were reviewed and divided into the routine dose group(n=60)who received rosuvastatin routine dose therapy after PCI and the intensification therapy group(n=46)who received rosuvastatin intensification therapy after PCI.The differences in blood lipid metabolism,adipocytokines and plaque stability were compared between the two groups before and after treatment.Results:Before PCI,the differences in blood lipid metabolism,adipocytokines and plaque stability were not statistically significant between the two groups(P>0.05).1month after PCI,lipid metabolism indexes HDL-C and ApoA1levels in peripheral blood of intensification therapy group were higher than those of routine dose group while LDL-C and ApoB levels were lower than those of routine dose group;adipocytokines APN and Leptin levels in serum were higher than those of routine dose group while Resistin level was lower than that of routine dose group;plaque stability-related indexes ICAM-1,MMP-1and TIMP-1levels were lower than those of routine dose group(P<0.05).Conclusion:Rosuvastatin intensification therapy after PCI could effectively regulate the lipid metabolism and increase the plaque stability in ACS patients.

关 键 词：ACS 瑞舒伐他汀 血脂代谢 脂肪细胞因子 斑块稳定性 

分 类 号：R541.4[医药卫生—心血管疾病]