前列地尔对新生儿持续性肺动脉高压呼吸参数及血流动力学的影响  

Effects of alprostadil on respiratory parameters and hemodynamics in newborns with persistent pulmonary hypertension

作　　者：张岚[1] 刘艳[1] 高琼 张静[1] 王惠萍[1] ZHANG Lan;LIU Yan;GAO Qiong;ZHANG Jing;WNAG Hui-ping(Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China)

机构地区：[1]西安交通大学第二附属医院儿科,陕西西安710004

出　　处：《海南医学院学报》2017年第19期2698-2700,2704,共4页Journal of Hainan Medical University

基　　金：陕西省卫生厅科研基金(2016E29)~~

摘　　要：目的:探讨前列地尔对新生儿持续性肺动脉高压呼吸参数及血流动力学的影响。方法:80例患有肺动脉高压的新生儿依据随机数据表法分为对照组(n=40)和观察组(n=40),对照组患者接受常频通气治疗,观察组患者在对照组的基础上给予前列地尔治疗。比较治疗前后两组呼吸参数及血流动力学的变化。结果:治疗前,两组呼吸参数(SaO_2、PaO_2、PaCO_2)、血流动力学参数(PA、PVR、SVR)水平比较,差异无统计学意义(P>0.05)。治疗后,两组SaO_2、PaO_2水平较组内治疗前均显著升高(P<0.05),且观察组SaO_2、PaO_2水平显著高于治疗后对照组,差异有统计学意义(P<0.05);两组PaCO_2、PA、PVR及SVR水平均显著低于本组治疗前(P<0.05),且观察组PaCO_2、PA、PVR及SVR水平显著低于对照组,差异有统计学意义(P<0.05)。结论:常频通气治疗的基础上加用前列地尔治疗新生儿PPHN,可有效提高患儿血氧分压和血氧饱和度,改善患儿血流动力学,具有重要临床价值。Objective:To investigate the effects of alprostadil on respiratory parameters and hemodynamics of newborns with persistent pulmonary hypertension.Methods:According to random data table method,80newborns of pulmonary hypertension were randomly divided into the control group(n=40)and observation group(n=40),patients in the control group were given normal frequency ventilation,on the basis of the treatment of the control group,the observation group received alprostadil.The changes of respiratory parameters and hemodynamics were compared between the two groups before and after treatment.Results:The levels of respiratory parameters(SaO2,PaO2,PaCO2)and hemodynamics(PA,PVR,SVR)in the two groups before treatment were not statistically significant(P>0.05).After treatment,The levels of SaO2,PaO2in the two groups were significantly higher than those in the same group before treatment(P<0.05),and the observation group levels were(90.71±8.92)%,(85.27±8.23)mmHg,which were significantly higher than those in the control group after treatment(P<0.05);The levels of PaCO2,PA,PVR and SVR in the two groups after treatment were significantly lower than those in the same group before treatment(P<0.05),and the observation group were(35.22±3.46)mmHg,(26.95±3.78)mmHg,(725.71±108.82)dyns/cm5,(1125.27±152.23)dyns/cm5,which were significantly lower than that of the control group(P<0.05).Conclusion:Adding alprostadil based on conventional frequent ventilation thraphy can effectively improve blood pressure and oxygen saturation,and improve hemodynamics of newborns with persistent pulmonary hypertension,which has important clinical value.

关 键 词：前列地尔 新生儿肺动脉高压 呼吸参数 血流动力学 

分 类 号：R722[医药卫生—儿科]