亚低温联合VitC、EPO治疗对新生儿窒息患儿靶器官损伤的影响  

Effect of mild hypothermia combined with VitC and EPO therapy on target organ damage in children with neonatal asphyxia

作　　者：王淑云[1] WANG Shu-yun(Department of Neonatology, Taihe County People's Hospital in Anhui Province, Taihe County, Anhui Province, 236600, China)

机构地区：[1]安徽省太和县人民医院新生儿科,安徽太和236600

出　　处：《海南医学院学报》2017年第19期2705-2707,2711,共4页Journal of Hainan Medical University

基　　金：阜阳市卫生局科研基金(2013-19)~~

摘　　要：目的:研究亚低温联合维生素C(VitC)、促红细胞生成素(EPO)治疗对新生儿窒息患儿靶器官损伤的影响。方法:选择本院收治的新生儿窒息患儿并随机分为两组,亚低温组接受亚低温联合VitC、EPO治疗,对照组接受VitC、EPO治疗。治疗前及治疗后3、7天时,测定血清中靶器官功能损伤标志物、氧化应激指标、细胞凋亡指标的含量。结果:治疗后3、7天时,两组血清中NSE、H-FABP、cTnI、CysC、MDA、Caspase-3、PDCD5、sFas、sFasL的含量均显著低于治疗前,TAS、SOD、GSH、Bcl-2的含量显著高于治疗前且亚低温组血清中NSE、H-FABP、cTnI、CysC、MDA、Caspase-3、PDCD5、sFas、sFasL的含量均显著低于对照组,TAS、SOD、GSH、Bcl-2的含量显著高于对照组。结论:亚低温联合VitC、EPO治疗能够通过抑制氧化应激反应及细胞凋亡来减轻新生儿窒息患儿的靶器官损伤。Objective:To study the effect of mild hypothermia combined with vitamin C(VitC)and erythropoietin(EPO)therapy on target organ damage in children with neonatal asphyxia.Methods:Children with neonatal asphyxia who were treated in Taihe County People's Hospital between April2014and February2017were selected and randomly divided into two groups,mild hypothermia group received mild hypothermia combined VitC and EPO therapy,and control group received VitC and EPO therapy.Serum levels of of target organ damage markers,oxidative stress indexes and apoptosis indexes were measured before treatment as well as3days and7days after treatment.Results:3days and7days after treatment,serum NSE,H-FABP,cTnI,CysC,MDA,Caspase-3,PDCD5,sFas and sFasL levels of both groups of children were significantly lower than those before treatment while TAS,SOD,GSH and Bcl-2levels were significantly higher than those before treatment,and serum NSE,H-FABP,cTnI,CysC,MDA,Caspase-3,PDCD5,sFas and sFasL levels of mild hypothermia group were significantly lower than those of control group while TAS,SOD,GSH and Bcl-2levels were significantly higher than those of control group.Conclusion:Mild hypothermia combined with VitC and EPO therapy can reduce the target organ damage of children with neonatal asphyxia by inhibiting oxidative stress and apoptosis.

关 键 词：新生儿窒息 亚低温 靶器官 氧化应激 凋亡 

分 类 号：R722.12[医药卫生—儿科]