不同程度老年支气管哮喘呼出一氧化氮水平与肺功能的相关性研究  

Correlation between exhaled nitric oxide and pulmonary function in elderly patients with bronchial asthma

作　　者：吴国斌[1] 赖庆文[1] 曾省都[1] 袁平[1] 刘晓妮[1] 文慧兰[1] WU Guobin;LAI Qingwen;ZENG Shengdu;YUAN Ping;LIU Xiaoni;WEN Huilan(Department of Respiratory Medicine,First Affiliated Hospitai of Gannan Medicai College,Ganzhou341000,China))

机构地区：[1]赣南医学院第一附属医院呼吸内科,江西赣州341000

出　　处：《国外医学（医学地理分册）》2017年第4期387-390,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：赣州市科技计划资助项目(No.G20017ZSF070)

摘　　要：目的探讨不同程度老年支气管哮喘呼出一氧化氮水平(FeNO)与患者肺功能的相关性。方法选择本院老年支气管哮喘患者共74例,检测患者FeNO水平、肺功能、外周静脉血嗜酸性粒细胞(Eos)与中性粒细胞(N)水平,治疗后评价支气管哮喘控制水平,分析不同控制水平支气管哮喘患者FeNO与肺功能的相关性。结果 FeNO、Eos比率、N比率检测结果显示,治疗后完全控制的患者其结果均显著低于良好控制的患者和未控制的患者(P<0.05),良好控制的患者显著低于未控制的患者(P<0.05)。FEV1、FEV1/pred检测结果显示,治疗后完全控制的患者其结果均显著高于良好控制的患者和未控制的患者(P<0.05),良好控制的患者显著高于未控制的患者(P<0.05)。FeNO与N比率、Eos比率呈显著的正相关,FeNO与FEV1、FEV1/pred呈显著的负相关。结论老年支气管哮喘患者呼出一氧化氮水平与肺功能具有显著相关性,FeNO测量可作为评估老年支气管哮喘患者肺功能的潜在方法。Conclusion To investigate the correlation between exhaled nitric oxide(FeNO)and lung functionin elderly patients with bronchial asthma.Methods A total of74elderly patients with bronchial asthma were selected.The FeNO level,pulmonary function and peripheral blood eosinophil(Eos)and neutrophil(N),and the degrees of asthma control were evaluated after treatment.The correlation between FeNO and pulmonary function was analyzed.Results Patients with complete control after treatment had significantly lower FeNO,Eos ratio and N ratio than those with good control and poor control(P<0.05),and patients with good control had significantly lower FeNO,Eos ratio and N ratio than those with poor control(P<0.05).Patients with complete control after treatment had significantly higher FEV1and FEV1/pred than those with good control and poor control(P<0.05),and patients withgood control had significantlyhigherFEV1and FEV1/pred than those withpoor control(P<0.05).FeNO was positively correlated with N ratioand Eos ratio,while negatively correlated with FEV1and FEV1/pred.Conclusion There was a significant correlation between exhaled nitric oxide and pulmonary functionin elderly patients with bronchial asthma.

关 键 词：不同控制水平 老年支气管哮喘患者 呼出一氧化氮 肺功能 

分 类 号：R562[医药卫生—呼吸系统]