乌司他丁+胸腺肽辅助治疗对重症肺炎患者炎症及应激反应的影响  

Effect of ulinastatin+thymosin adjuvant therapy on inflammatory and stress response in patients with severe pneumonia

作　　者：汪江[1] 杨亚东[1] 佘秋芳 陈桂芬 WANG Jiang;YANG Ya-dong;SHE Qiu-fang;CHEN Gui-fe(Department of Critical Care Medicine, Huanggang Central Hospital in Hubei Province, Huanggang, Hubei Province, 438000;Department of Humanities and Management, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, 350122)

机构地区：[1]湖北省黄冈市中心医院重症医学科,湖北黄冈438000 [2]福建中医药大学人文与管理学院,福建福州350122

出　　处：《海南医学院学报》2017年第24期3370-3372,3376,共4页Journal of Hainan Medical University

基　　金：湖北省黄冈市卫生局一般规划项目(HW-2009BNO.017)~~

摘　　要：目的:探讨乌司他丁+胸腺肽辅助治疗对重症肺炎患者炎症及应激反应的影响。方法:收集2016年7月~2017年7月间在黄冈市中心医院确诊并接受治疗的重症肺炎患者66例,经随机数表法分为对照组、研究组,各33例。对照组患者接受临床重症肺炎常规治疗,研究组患者在常规治疗基础上加入乌司他丁、胸腺肽辅助治疗,持续1周。对比两组患者治疗前后血清炎症因子、应激激素含量的差异。结果:治疗前,两组患者血清中炎症因子、应激激素含量的差异无统计学意义(P>0.05),治疗1周后,两组患者血清中炎症因子、应激激素的含量均较治疗前低(P<0.05),且研究组血清中促炎因子IL-1β、IL-2、IL-6、IL-8、TNF-α及抗炎因子IL-4、IL-10、IL-13的含量较对照组低(P<0.05),血清中应激激素AngⅠ、AngⅡ、NE、Cor的含量较对照组低(P<0.05)。结论:重症肺炎患者在常规治疗同时给予乌司他丁+胸腺肽辅助治疗,可进一步抑制机体全身炎症反应及应激反应,优化整体病情。Objective:To investigate the effect of ulinastatin+thymosin adjuvant therapy on inflammatory and stress response in patients with severe pneumonia.Methods:66patients with severe pneumonia who were diagnosed and treated in Huanggang Central Hospital between July2016and July2017were divided into control group(n=33)and study group(n=33)by random number table.Control group received routine therapy for severe pneumonia,and study group received routine therapy combined with ulinastatin+thymosin adjuvant therapy,which lasted for1week.The differences in serum levels of inflammatory factors and stress hormones were compared between the two groups before and after treatment.Results:Before treatment,the differences in serum levels of inflammatory factors and stress hormones were not statistically significant between the two groups.After1week of treatment,serum levels of inflammatory factors and stress hormones of both groups of patients were lower than those before treatment,serum levels of pro-inflammatory factors IL-1β,IL-2,IL-6,IL-8and TNF-αas well as anti-inflammatory factors IL-4,IL-10and IL-13of study group were lower than those of control group,and serum stress hormones AngⅠ,AngⅡ,NE and Cor levels were lower than those of control group.Conclusion:Routine therapy combined with ulinastatin+thymosin adjuvant therapy can further inhibit the systemic inflammatory response and stress response and optimize the overall condition in patients with severe pneumonia.

关 键 词：重症肺炎 乌司他丁 胸腺肽 炎症因子 应激激素 

分 类 号：R563.1[医药卫生—呼吸系统]