新生儿感染性肺炎血清中sTREM-1含量与炎性因子、免疫功能的相关性研究  

The correlation of serum sTREM-1 content with inflammatory factors and immune function in neonatal infectious pneumonia

作　　者：何源[1] 易海英[1] 杨树杰[1] 黄杰[1] 魏贤[1] HE Yuan;YI Hai-ying;YANG Shu-jie;HUANG Jie;WEI Xian(Neonatology Department, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei Province, 432000)

机构地区：[1]武汉科技大学附属孝感医院新生儿科,湖北孝感432000

出　　处：《海南医学院学报》2017年第24期3408-3410,3414,共4页Journal of Hainan Medical University

基　　金：湖北省医学科技计划项目(2015-2016)(WJ2015Z124)~~

摘　　要：目的:探讨新生儿感染性肺炎血清中可溶性髓系细胞触发受体-1(sTREM-1)含量与炎性因子、免疫功能的相关性。方法:2016年7月~2017年9月在武汉科技大学附属孝感医院接受治疗的新生儿感染性肺炎62例作为肺炎组,同期在本院分娩的健康新生儿50例作为正常对照组。对比两组新生儿血清中sTREM-1的含量,炎性因子及免疫球蛋白含量的差异。结果:肺炎组血清中sTREM-1的含量高于正常对照组(P<0.05);血清中细胞因子IL-10、IL-17、PCT、CRP的含量均高于正常对照组(P<0.05);血清中免疫球蛋白IgA、IgG、IgM的含量高于正常对照组(P<0.05);肺炎组中sTREM-1高含量新生儿血清中IL-10、IL-17、PCT、CRP、IgA、IgG、IgM的含量高于sTREM-1低含量新生儿(P<0.05)。结论:感染性肺炎新生儿血清中sTREM-1的含量较高,与机体炎症反应程度、体液免疫功能直接相关。Objective:To investigate the correlation of serum soluble triggering receptors expressed on myeloid cells1(sTREM-1)content with inflammatory factors and immune function in neonatal infectious pneumonia.Methods:62neonates with infectious pneumonia who were treated in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology between July2016and September2017were selected as pneumonia group,and50healthy neonates who were born in this hospital during the same period were selected as normal control group.The differences in serum levels of sTREM-1,inflammatory factors and immunoglobulins were compared between the two groups.Results:Serum sTREM-1content of pneumonia group was higher than that of normal control group;serum cytokines IL-10,IL-17,PCT and CRP contents were higher than those of normal control group;serum immunoglobulins IgA,IgG and IgM contents were higher than those of normal control group;serum IL-10,IL-17,PCT,CRP,IgA,IgG and IgG contents of pneumonia group of neonates with high serum sTREM-1content were higher than those of neonates with low serum sTREM-1content.Conclusion:Serum sTREM-1content is higher in neonates with infectious pneumonia,which is directly correlated with the inflammatory response and humoral immune function.

关 键 词：新生儿感染性肺炎 可溶性髓系细胞触发受体-1(sTREM-1) 炎性因子 体液免疫 

分 类 号：R563.1[医药卫生—呼吸系统]