SAA遗传多态性与冠心病临床预后的关联研究  

Associations of SAA genetic polymorphisms with prognosis of coronary heart disease

作　　者：谢翔[1] 宋长来 吴雪琴[2] 郑颖颖[1] 刘芬[3] 吴婷婷[1] 李龙[1] 马依彤[1] XIE Xiang;SONG Changlai;WU Xueqin;ZHENG Yingying;LIU Fen;WU Tingting;LI Long;MA Yitong(Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China;Changji Branch Hospital, The First Affiliated Hospital, Xinjiang Medical University, Changji 831100, China;Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院昌吉分院心血管内科,新疆昌吉831100 [3]新疆医科大学第一附属医院新疆心血管病研究重点实验室,乌鲁木齐830054

出　　处：《新疆医科大学学报》2018年第1期1-5,共5页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(8156020057);新疆维吾尔自治区自然科学基金面上项目(2017D01A04)

摘　　要：目的探讨血清淀粉样蛋白A(SAA)基因多态性和冠心病预后的关系。方法采用队列研究的方法,选择经皮冠状动脉内介入治疗(PCI)术后冠心病患者1 068例,其基因分型采用限制性片段长度多态性(RFLP)技术,随访时间定为PCI术后1 a,随访终点为支架内血栓形成、非致死性心肌梗死、总死亡以及出血事件的发生率。结果研究结果发现,SAA基因多态性和冠心病PCI术后1 a心血管不良事件的发生无相关性。结论PCI术后患者SAA基因多态性和临床冠心病预后无关联性。ObjectiveTo analyze the relationship between SAA genetic polymorphisms and the prognosis of coronary artery disease(CAD)after PCI.MethodsA cohort study was designed to observe the relationship between SAA genetic polymorphisms and prognosis of1068patients with CAD after PCI.RFLP method was used to detect the genotypes.Total of1068patients were fellowed up for one year,and the outcomes such as stent thrombosis,nonfatal myocardial infarction,total mortality and bleeding events were recorded.ResultsThere was noany association of SAA genetic polymorphisms and adverse prognosis of CAD after PCI.ConclusionThe present study suggested thatthere was no relationship between SAA genetic polymorphisms and clinical outcomes of CAD after PCI.

关 键 词：血清淀粉样蛋白A 基因多态性 冠状动脉粥样硬化性心脏病 经皮冠状动脉内介入治疗 

分 类 号：R541.1[医药卫生—心血管疾病]