Sels基因遗传多态性与冠心病的关联研究  

Associations of Sels genetic polymorphisms with coronary artery disease

作　　者：谢翔[1] 吴雪琴[2] 宋长来 郑颖颖[1] 刘芬[3] 吴婷婷[1] 李龙[1] 马依彤[1] XIE Xiang;WU Xueqin;SONG Changlai;ZHENG Yingying;LIU Fen;WU Tingting;LI Long;MA Yitong(Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China;Changji Branch Hospital, The First Affiliated Hospital, Xinjiang Medical University, Chang ji 831100, China;Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院昌吉分院心血管内科,新疆昌吉831100 [3]新疆医科大学第一附属医院新疆心血管病研究重点实验室,乌鲁木齐830054

出　　处：《新疆医科大学学报》2018年第1期6-9,共4页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(8156020057);新疆维吾尔自治区青年科技创新人才培养工程(qn2015bs010和qn2015jq006)

摘　　要：目的探讨Sels基因多态性与冠状动脉粥样硬化性心脏病(冠心病)发生的相关性。方法本研究采用采病例-对照方法,选取于新疆医科大学第一附属医院行冠状动脉造影后的患者,根据纳入及排除标准,最终入选冠心病患者1 416例(冠心病组)和健康对照1 373例(对照组)。Sels基因分型采用TaqMan技术后,选取4个标签SNP(rs12910524,rs1384565,rs2101171和rs4965814)进行研究。结果 Sels基因rs1384656基因型分布在冠心病组和健康对照组中差异具有统计学意义。CC基因型在冠心病患者中的分布频率明显高于对照组,差异有统计学意义。多因素Logistic分析结果表明,排除了其他干扰因素后,rs1384656基因多态性仍然和冠心病的发病风险相关。结论 Sels基因多态性和冠心病的发生存在关联,可能Sels基因突变导致的血糖、血脂变化、参与炎症调控有关。ObjectiveTo investigate the relationship between Sels gene polymorphism and coronary heart disease.MethodsA designed case-control study includes1416CAD patients and1373healthy controls.TaqMan technique was utilized and4SNPs of genotype(rs12910524,rs1384565,rs2101171and rs4965814)in Sels gene were selected to be the subjects.ResultsGenetics polymorphism of rs1384656of the Sels gene was related to CAD.Logistic regression analysis showed that CC genotype of Sels was independently correlated with CAD risk excluding the confounders.ConclusionThe present study indicated that Sels genetic polymorphism was associated with CAD risk in the population,possibly since Sels gene mutations resulted in changes of blood sugar and lipid,and involved in the regulation of inflammation.

关 键 词：Sels 基因多态性 冠状动脉粥样硬化性心脏病 

分 类 号：R541.1[医药卫生—心血管疾病]