Tanis遗传多态性与冠心病临床预后的关联分析  

Associations of tanis genetic polymorphisms with prognosis of coronary artery disease

作　　者：谢翔[1] 宋长来 吴雪琴[2] 郑颖颖[1] 刘芬[3] 吴婷婷[1] 李龙[1] 马依彤[1] XIE Xiang;SONG Changlai;WU Xueqin;ZHENG Yingying;LIU Fen;WU Tingting;LI Long;MA Yitong(Department of Cardiology, The First Affliated Hospital, Xinjiang Medical University, Urumqi 830054, China;Changji Branch Hospital, The First Affliated Hospital, Xinjiang Medical University, Changji 831100, China;Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China)

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院昌吉分院心血管内科,新疆昌吉831100 [3]新疆医科大学第一附属医院新疆心血管病研究重点实验室,乌鲁木齐830054

出　　处：《新疆医科大学学报》2018年第1期10-13,17,共5页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(8156020057);新疆维吾尔自治区自然科学基金面上项目(2017D01A04))

摘　　要：目的探讨Tanis基因遗传变异与冠心病患者经皮冠状动脉内介入治疗(PCI)术后预后的关系。方法本研究中我们采用前瞻性设计的方法,共纳入PCI术后患者1 068例,Tanis基因分型的方法采用Taq Man技术,选取rs1384656位点进行研究。所有患者随访1 a,观察不同遗传表型患者临床结局的差异。结果研究结果显示,Tanis基因遗传变异没有改变冠心病患者PCI术后的临床结局。不同基因型之间比较,支架内血栓、非致死性心肌梗死以及死亡率未见明显差异。结论 Tanis基因遗传变异和冠心病患者PCI术后临床结局无明显关联。Objective To analyze the relationship between Tanis genetic variation and the prognosis of coronary artery disease after PCI.MethodsA cohort study was used to analyze the association of Tanis genetic variation and the prognosis of1068CAD patients after PCIthroughTacMantechniqueand selecting rs1384656as the subjects.ResultsThe genetic polymorphism of Tanis gene did not change the clinical outcome of patients with CAD after PCI.There was no significant difference in stent thrombosis,non fatal myocardial infarction and mortality among different genotypes.ConclusionThe present study indicated that Tanis genetic variation was not associated with CAD clinical outcomes after PCI.

关 键 词：Tanis 基因多态性 冠状动脉粥样硬化性心脏病 经皮冠状动脉内介入治疗 

分 类 号：R541.1[医药卫生—心血管疾病]