阿魏酸钠对糖尿病肾病患者肠道菌群的影响  

Effect of sodium ferulate on intestinal flora in patients with diabetic nephropathy

作　　者：王利民[1] 池文婕 王玮[3] 张择伟 宋彦丽 杨倩如 支姗 康金旺[1] 姜兰叶[3] WANG Limin;CHI Wenjie;WANG Wei;ZHANG Zewei;SONG Yanli;YANG Qianru;ZHI Shan;KANG Jinwang;JIANG Lanye(Department of Gastroenterology,The Second Affiliated Hospital of Hebei North University, Hebei ZhangJiakou 075100,China;Department of Nursing,The Second Affiliated Hospital of Hebei North University, Hebei ZhangJiakou 075100,China;Department of Endocrinology,The Second Affiliated Hospital of Hebei North University, Hebei ZhangJiakou 075100,China)

机构地区：[1]河北北方学院附属第二医院消化内科,河北张家口075100 [2]河北北方学院附属第二医院护理部,河北张家口075100 [3]河北北方学院附属第二医院内分泌科,河北张家口075100

出　　处：《新疆医科大学学报》2018年第1期21-24,共4页Journal of Xinjiang Medical University

基　　金：河北省卫生和计划生育委员会计划项目(162777257)

摘　　要：目的探讨阿魏酸钠对糖尿病肾病(DN)患者肠道菌群的影响作用。方法选取2016年4月-2017年4月河北北方学院附属第二医院消化内科收治的DN患者40例为研究对象,随机分为对照组和阿魏酸钠组,对照组患者给予CCB类控制血压、他汀类调节血脂、口服降糖药或胰岛素控制血糖、心率较快者加β-受体阻滞剂、优质蛋白饮食,阿魏酸钠组患者在对照组基础上联合阿魏酸钠进行治疗,2组患者均治疗1个月后进行评价。抽取治疗前后空腹外周静脉血,采用葡萄糖氧化酶法测定空腹血糖(FBG),放射免疫法测定血尿素氮(BUN)、24 h尿白蛋白清除率(24 h UAER),ELISA法测定血肌酐(SCr)、β2-微球蛋白(β2-MG)。收集患者粪便标本,采用稀释直接涂片、革兰染色测定肠道菌群情况,记录每500个细菌中的革兰氏阳性杆菌(G^+b)、革兰氏阴性杆菌(G-b)、革兰氏阳性球菌(G^+c)、革兰氏阴性球菌(G-c),计算球菌/杆菌比值(c/b)。结果与对照组比较,治疗后阿魏酸钠组患者FPG、BUN、24h UAER、SCr、β2-MG指标均降低,差异有统计学意义(P<0.01);与对照组比较,治疗后阿魏酸钠组患者G^+b、G-b指标升高,c/b指标降低,差异有统计学意义(P<0.05)。结论联合阿魏酸钠可有效控制DN患者血糖水平,调节肠道菌群,增加肾小球滤过,改善肾功能,值得临床进一步研究。ObjectiveTo investigate the effect of sodium ferulate on intestinal flora in patients with diabetic nephropathy(DN).Methods40DN patients selected from April2016to April2017in the hospital were randomly divided into sodium ferulate group and control group,both the2groups was treated with normal treatments on blood pressure,lipid and glucose,and heart rate as well as high protein diet,based on that,sodium ferulate treatment group was combined with sodium ferulate,After1months,relative data of intestinal flora and DN syndrome were determined.ResultsCompared with the control group,the levels of glucose oxidase method(FBG),blood urea nitrogen were measured by radioimmunoassay(BUN),24h urinary albumin clearance rate(24h UAER),serum creatinine(SCr),beta2microglobulin(β2MG)in the sodium ferulate group were decreased after treatment,and the difference was statistically significant(P<0.01);compared with the control group,gram positive bacilli in bacteria(G+b)and gram negative bacilli(G-b)indexes in sodium ferulate group increased after treatment,gram negative cocci(G-c)/bacilli(c/b)index was decreased,and the difference was statistically significant(P<0.05).ConclusionThe combination of sodium ferulate can effectively control the blood sugar level of patients with DN,regulate intestinal flora,increase glomerular filtration,improve renal function,and is worthy of further clinical study.

关 键 词：阿魏酸钠 糖尿病肾病 肠道菌群 肾功能 

分 类 号：R587.1[医药卫生—内分泌]