布洛陀壮族H型高血压与颈动脉粥样斑块的相关性分析  

Correlation analysis of H type hypertension and carotid atherosclerotic plaque in Buluotuo Zhuang nationality

作　　者：江洪[1] 罗蓓蓓[2] 刘洪[1] 韦明[1] 罗钢[1] 农秋妮 何玫 钟诗颖[2] JIANG Hong;LUO Beibei;LIU Hong;WEI Ming;LUO Gang;NONG Qiuni;He Mei;ZHONG Shiying(Department of Cardiology,People’s Hospital of Tianyang,Tianyang533600;Institute of Cardiovascular Diseases,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西百色市田阳县人民医院心内科,田阳533600 [2]广西医科大学第一附属医院心血管病研究所,南宁530021

出　　处：《右江医学》2017年第6期659-663,共5页Chinese Youjiang Medical Journal

基　　金：百色市科技局资助项目(百科计20160633)

摘　　要：目的探讨田阳县布洛陀壮族患者H型高血压与颈动脉粥样斑块的相关性。方法选取2015年1月~12月在体检部、门诊和住院的174例布洛陀壮族高血压患者作为研究对象,根据同型半胱氨酸(Hcy)水平,分为H型高血压组(Hcy≥10μmol/L)102例及单纯型高血压组(Hcy<10μmol/L)72例,比较两组患者心脏彩超、颈动脉内膜中层厚度、尿酸、血肌酐(Scr)、总胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三酯、同型半胱氨酸,同时分层分析比较H型高血压组颈动脉斑块形成患者及无颈动脉斑块形成患者的以上指标。结果 H型高血压组中颈动脉内膜中层厚度超过正常值的患者比例以及Scr水平高于单纯型高血压组(P<0.05);H型高血压组中,颈动脉斑块形成患者的同型半胱氨酸水平高于无颈动脉斑块组(P<0.05),左室收缩末径显著小于无颈动脉斑块患者(P<0.05),颈动脉内膜中层厚度超过正常值的患者比例以及Scr水平高于无颈动脉斑块组(P<0.001),其余指标组间比较差异无统计学意义(P>0.05)。经Logistic回归分析发现,高同型半胱氨酸、颈动脉内膜中层增厚及血肌酐升高是颈动脉斑块形成的独立影响因素。结论在布洛陀壮族居民中,H型高血压与颈动脉斑块形成密切相关,H型高血压颈动脉斑块形成的发生率较高,高同型半胱氨酸、颈动脉内膜中层厚度增加及血肌酐升高可能是导致颈动脉斑块形成的独立危险因素。Objective To investigate the correlation between H type hypertension and carotid atheroscleurotic plaque in Buluotuo Zhuang nationality in Tiangyang.Methods174patients with hypertension in Zhuang Nationality who admitted to Physical Examination Department,Outpatient Department and Inpatient Department from January to December,2015were selected as the subjects of study.They were divided into H type hypertension group(Hcy≥10μmol/L,102cases)and simple hypertension group(Hcy<10μmol/L,72cases)according to the levels of homocysteine(Hcy).Colour Doppler echocardiography,intima media thickness,carotid intima-media thickness(CIMT),uric acid(UA),serum creatinine(Scr),total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),triglyceride(TG)and homocysteine(Hcy)were compared between the two groups.What’s more,simultaneous stratification analysis and comparison were performed in the above-mentioned indexes in patients with and without carotid atherosclerotic plaque in the H type hypertension group.Results The proportion of patients with CIMT exceeding normal value and Scr in the H type hypertension group were higher than those of the simple hypertension group(P<0.05).In the H type hypertension group,the Hcy levels of patients with carotid atherosclerotic plaque were higher than those of patients without carotid atherosclerotic plaque(P<0.05),left ventricular end systolic diameter(LVSD)was smaller than that of patients without carotid atherosclerotic plaque(P<0.05),the proportion of CIMT exceeding normal value and Scr were higher than those of patients without carotid atherosclerotic plaque(P<0.001),and there was no statistically significant difference in comparison of other indexes among groups(P>0.05).Logistic regression analysis showed that the high levels of Hcy and Scr,increased CIMT were risk factors leading to carotid atherosclerotic plaque.Conclusion Among inhabitants of Buluotuo Zhuang nationality,H type hypertension is closely related to formation of caroti

关 键 词：布洛陀壮族 H型高血压 颈动脉粥样斑块 

分 类 号：R544.1[医药卫生—心血管疾病]