依诺肝素对STEMI体内炎症标志物的影响  

Effects of Enoxaparin on Inflammatory Biomarkers in Patients with STEMI

作　　者：张俊伟[1] 马俊贤[1] 曹劝省[1] ZHANG Jun wei;MA Jun xian;CAO Quan sheng(Clinical Medical College of Henan University of Science and Technology;First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,河南科技大学第一附属医院,河南洛阳471000

出　　处：《河南科技大学学报（医学版）》2017年第4期270-273,共4页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的比较普通肝素与依诺肝素对ST段抬高性心肌梗死(STEMI)体内炎症标志物的影响。方法36例STEMI患者随机分为两组各18例,分别接受标准剂量普通肝素和依诺肝素注射治疗。检测两组注射前及注射后12、24、48 h血清中炎症因子血清淀粉样蛋白A(SAA),白细胞介素6(IL-6)、铁蛋白(Ferritin)、C反应蛋白(CRP)和髓过氧化物酶(MPO)水平。结果普通肝素组血清SAA、CRP和Ferritin浓度治疗后较治疗前明显降低(均P<0.05),依诺肝素组血清SAA、CRP和IL-6浓度治疗后较治疗前明显降低(均P<0.05)。普通肝素与依诺肝素组治疗后炎症标志物水平整体差异无统计学意义(P>0.05)。结论普通肝素和依诺肝素不仅具有抗凝的作用,同时还能明显降低血清中的炎症因子水平,而且二者对于抗炎的作用无明显差异。ObjectiveTo compare the effects of heparin and enoxaparin on inflammatory biomarkers in patients with ST elevated myocardial infarction(STEMI).MethodsThirty six patients with STEMI randomly separated in two groups(each of18cases),which respectively received standard doses of heparin and enoxaparin.The serum concentration of serum amyloid A(SAA),C reactive protein(CRP),interleukin(IL6),ferritin and myeloperoxidase(MPO)were measured at baseline,12,24and48hours after the drug administration.ResultsSerum concentrations of SAA,CRP and ferritin significantly reduced in heparin group during measurements compared to baseline(all P<0.05).The circulating levels of IL6,SAA,CRP were significantly decreased in enoxaparin group(all P<0.05).The overall difference in inflammatory biomarkers was not significant between heparin and enoxaparin group(P>0.05).ConclusionBoth heparin and enoxaparin reduced serum levels of inflammatory biomarkers in patients with STEMI.This effect might provide additional clinical benefit of these drugs in treatment STEMI patients.

关 键 词：ST段抬高性心肌梗死 依诺肝素 炎症标志物 

分 类 号：R541.4[医药卫生—心血管疾病] R542.22[医药卫生—内科学]