基质血管片段促进脂肪移植后再血管化的机制研究进展  

Mechanism of Promoted Neovascularization by SVF after Fat Grafting

作　　者：汪正财 顾子春[1] 李奕润 李华[1] WANG Zhengcai;GU Zichun;LI Yirun;LI Hua(Department of Plastic and Reconstructive Surgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, China.)

机构地区：[1]浙江大学医学院附属邵逸夫医院整形外科,浙江省杭州市310003

出　　处：《组织工程与重建外科杂志》2017年第6期349-353,共5页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：浙江省自然科学基金项目(LY14H150001)

摘　　要：基质血管片段(Stromal vascular fraction,SVF)是移植的脂肪组织中去除成熟脂肪细胞后所剩余的细胞成分,除含有一定数量的脂肪来源干细胞(Adipose Derived Stem Cells,ADSC)外,还有许多其他细胞,均具有促进血管生成的作用。本文通过对近年来相关研究文献进行综述,以阐明SVF促进脂肪移植后再血管化的机制。综合文献结果,血管的再生与形成受多种因素调控,SVF细胞不仅可分泌多种因子,协同促进血管再生,还具有周细胞形态可稳定内皮网络。而SVF包含的ADSC具有多向分化潜能,包含的脂肪巨噬细胞在缺氧环境下可促进局部血管生成,有望为临床上提高自体脂肪移植的存活率提供方向。Stromal vascular fraction(SVF)are the remaining cells of the ingredients after removing mature fat cells in the adipose tissue of transplantation.In addition to containing a certain amount of adipose derived stem cells(ADSC),SVF also includes many other cells,which may all have the potential of promoting angiogenesis.In this paper,the role of SVF in angiogenesis after fat transplantation was summarized by reviewing relative literature in recent years.According to the literature,angiogenesis and fat graft revascularization are regulated by various factors:SVF promotes secretion of a diverse array of cytokines and growth;SVF differentiated to pericytes has the function of stabilizing endothelium vascular network;As components of SVF,adipose derived stem cells(ADSC)have the potential of multi-directional differentiation,and macrophages can promote local angiogenesis in hypoxia environment.These results may provide directions of improving the survival rate of fat cells in clinical autologous fat transplantation.

关 键 词：基质血管片段 再血管化 脂肪移植 脂肪来源干细胞 巨噬细胞 

分 类 号：R622.9[医药卫生—整形外科]