皮肤γδT细胞在维持上皮完整和伤口愈合中的作用  

Skin γδT-Cell Functions in Epithelium Integrity and Wound Healing

作　　者：王配合[1] 何泽亮 李晓东[1] 安亮恩[1] 卓勤强[1] 刘玲玲[1] WANG Peihe;HE Zeliang;LI Xiaodong;AN Liangen;ZHUO Qinqiang;LIU Lingling(Department of Burns and Plastic Surgery, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China.)

机构地区：[1]中国人民解放军白求恩国际和平医院烧伤整形科,河北省石家庄市050082

出　　处：《组织工程与重建外科杂志》2017年第6期354-356,共3页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：研究证实小鼠皮肤树突状表皮γδT细胞(Dendritic epidermalγδT cells,DETCs)表达的γδTCR,由Vγ3Jγ1-Cγ1和Vδ1Dδ2Jδ2-Cδ链组成,特异性表达于成年小鼠皮肤中。DETCs活化后分泌多种细胞因子、生长因子、趋化因子等,这些因子与组织修复,以及细胞存活、增殖、迁移和募集有关,在维持上皮组织完整性和上皮组织修复中发挥关键作用。本文就DETCs在维持上皮组织的完整和组织修复过程中的作用进行综述。The research showed that the dendritic epidermalγδT cells(DETCs)found in murine skin expressed aγδTCR composed of Vγ3Jγ1-Cγ1and Vδ1Dδ2Jδ2-Cδchains which specifically expressed in murine skin.Activated DETCs produce several cytokines,growth factors and chemokines.All these factors were related to tissue repair,cell survival,proliferation,migration,recruitment,and play a key role in maintaining the epithelium integrity and repairing the epithelial tissue.In this paper,the functions of DETCs in maintaining the epithelium integrity and would repair were reviewed.

关 键 词：ΓΔT细胞 上皮完整 组织修复 皮肤 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]