巨噬细胞在骨折愈合过程中作用的研究进展  

Research progress on role of macrophage in fracture healing

作　　者：周潇逸[1] 吴随一 张子程 王飞[1] 杨依林[1] 徐锡明[3] 李明[1] 魏显招[1] ZHOU Xiao-yi;WU Sui-yi;ZHANG Zi cheng;WANG Fei;YANG Yi-lin;XU Xi-ming;LI Ming;WEI Xian-zhao(Department of Spine Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;The Third Student Team, Student Brigade, Second Military Medical University, Shanghai 200433, China;Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China)

机构地区：[1]第二军医大学长海医院脊柱外科,上海200433 [2]第二军医大学学员旅学员3队,上海200433 [3]第二军医大学长征医院脊柱外科,上海200003

出　　处：《第二军医大学学报》2017年第12期1556-1561,共6页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81301554);上海市自然科学基金(13ZR1450200);上海市卫生与计划生育委员会科研课题(20154Y0018)~~

摘　　要：炎性反应对骨折愈合初期血肿形成、组织碎片清除及纤维组织生成具有重要作用。M1、M2型巨噬细胞分别通过促炎、抗炎作用参与骨折愈合过程。巨噬细胞分泌的肿瘤坏死因子α、白细胞介素等细胞因子可调节成骨/破骨细胞活性。骨组织生物工程学研究通过功能型组织工程调节骨折局部炎性反应,可促进血管新生及骨折愈合。因此,探究巨噬细胞在骨折愈合过程中的作用可以为促进骨折愈合提供新思路。Inflammatory reaction plays an important role in hematoma formation,tissue debris removal and fibrous tissue formation during the first stage of fracture healing.M1and M2macrophages participate in the process of fracture healing through pro inflammatory and anti inflammatory effects,respectively.Tumor necrosis factorα,interleukin and other cytokines secreted by macrophages can regulate the activities of osteoblasts and osteoclasts.Bone tissue bioengineering studies found that functional tissue engineering can promote angiogenesis and fracture healing by regulating inflammatory reaction.Therefore,exploring the role of macrophages in the process of fracture healing may provide new insights for promoting fracture healing.

关 键 词：组织工程 巨噬细胞 骨折 炎症 愈合 

分 类 号：R602[医药卫生—外科学]