硫酸钙人工骨联合同种异体骨与单纯人工骨治疗下肢良性骨肿瘤的对比研究  

Calcium sulfate artificial bone combined with allograft bone versus calcium sulfate artificial bone alone in treatment of benign bone tumor in lower limbs:a comparative study

作　　者：刘畅[1,2] 乔苏迟[1] 王志伟 李诚[1] 曹烈虎[3] 苏佳灿[3] LIU Chang;QIAO Su-chi;WANG Zhi-wei;LI Cheng;CAO Lie-hu;SU Jia-can(Department of Joint and Bone Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Department of Orthopaedics (Ⅱ), Fuzhou General Hospital, Fuzhou 350025, Fujian, China;Department of Trauma Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)

机构地区：[1]第二军医大学长海医院关节骨病外科,上海200433 [2]福州总医院骨二科,福州350025 [3]第二军医大学长海医院创伤骨科,上海200433

出　　处：《第二军医大学学报》2017年第12期1581-1585,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金(81671199)~~

摘　　要：目的评价硫酸钙颗粒人工骨联合同种异体骨与单纯使用硫酸钙颗粒人工骨植骨治疗下肢良性骨肿瘤的效果。方法回顾性分析第二军医大学长海医院关节骨病外科2010年6月至2015年6月收治的符合研究条件的97例下肢良性骨肿瘤患者的临床资料,其中32例患者接受硫酸钙颗粒人工骨联合同种异体骨植骨治疗(联用组),另65例患者接受单纯硫酸钙颗粒人工骨植骨治疗(单用组)。比较并分析两组患者术后的切口不良事件、人工骨完全吸收后的骨质愈合情况等。结果联用组和单用组患者术后切口不良事件的发生率分别为15.6%(5/32)和26.2%(17/65),两组差异无统计学意义(P>0.05)。联用组和单用组患者在硫酸钙颗粒人工骨完全吸收后,遗留明确或可疑骨缺损的发生率分别为9.4%(3/32)和29.2%(19/65),两组差异有统计学意义(P=0.028)。结论硫酸钙颗粒人工骨联合同种异体骨植骨治疗下肢良性骨肿瘤具有良好的效果,两者的联合使用不会增加切口不良事件的发生风险,并且可能降低人工骨被完全吸收后遗留骨缺损的风险。ObjectiveTo evaluate the efficacy of calcium sulfate artificial bone combined with allograft bone and calcium sulfate artificial bone alone in the treatment of benign bone tumors in the lower limbs.MethodsWe retrospectively analyzed the clinical data of97patients with benign bone tumor in the lower limbs who received treatment in the Department of Joint and Bone Disease,Changhai Hospital,Second Military Medical University from June2010to June2015and met the study criteria.Thirty two patients received calcium sulfate artificial bone combined with allograft bone grafting(combined group),and the other65patients received calcium sulfate artificial bone grafting alone(artificial bone group).The incidence of postoperative incisional adverse events and the bone defect rate after the complete absorption of artificial bone of patients were compared between the two groups.ResultsThere was no significant difference in the incidence of postoperative incisional adverse events between the combined and artificial bone groups(15.6%[5/32]vs26.2%[17/65],P>0.05),while the bone defect rate after the complete absorption of artificial bone was significantly different between the two groups(9.4%[3/32]vs29.2%[19/65],P=0.028).ConclusionCalcium sulfate artificial bone combined with allograft bone has a satisfactory effect in the treatment of benign bone tumors in the lower limbs.The combination of the two may reduce the risk of bone defects after complete absorption of artificial boneand do not increase the adverse events of surgical incision.

关 键 词：硫酸钙 同种异体骨 骨代用品 骨肿瘤 骨移植 骨缺损 

分 类 号：R738.1[医药卫生—肿瘤] R687.34[医药卫生—临床医学]