天然产物抗肺癌作用机制研究进展  

Research progress on the mechanisms of natural products against lung cancer

作　　者：李伟 郑洁 保玉心 Li Wei;Zheng Jie;Bao Yuxin(Research Center for Medicine and Biology,Zunyi Medical University ,Zunyi Guizhou 563099 ,China;Center of Analysis and Measurement,Zunyi Medical University ,Zunyi Guizhou 563099 ,China)

机构地区：[1]遵义医学院医学与生物学研究中心,贵州遵义563099 [2]遵义医学院分析测试中心,贵州遵义563099

出　　处：《遵义医学院学报》2017年第6期697-702,共6页Journal of Zunyi Medical University

基　　金：国家自然科学基金资助项目(NO:31460006);贵州省科技计划项目(NO:黔科合SY字[2013]3013)

摘　　要：天然产物来源丰富且现已发现的抗癌药物很大一部分来自于天然产物,其对肺癌、乳腺癌、结肠癌、卵巢癌、胃癌、前列腺癌、肝癌等的作用效果显著,由于肺癌癌患死亡率居各恶性肿瘤之首,对天然产物抗肺癌及其作用机制的研究成为抗癌药物研究重点。因此本文对近年来不同来源的天然产物抗肺癌活性机制进行了综述,主要集中在诱导细胞凋亡、阻滞细胞周期、促组蛋白乙酰化、抑制缺氧诱导过程、提高活性氧水平、抑制肺癌侵袭和转移、逆转肺癌耐药等方面。以期为深入研究天然产物开发及抗癌创新药物的发现提供依据。Natural products are abundant in many sources.Recently,A large number of the anti-cancer drugs derived from natural products have been found to have significant effects on lung cancer,breast cancer,colon cancer,ovarian cancer,gastric cancer,prostate cancer,liver cancer and so on.Currently,lung cancer is the most concerned cancer among others,the mortality rate from lung cancer is highest of malignant tumors.The study of lung cancer and anticancer mechanisms of natural products has become the focus of research on anticancer drugs.In this paper,we reviewed the mechanisms of anti-lung cancer activity of natural products from different sources,they mainly included the induction of apoptosis,blocking cell cycle,promoting acetylation of histones,inhibiting hypoxia-inducing process,improving the level of reactive oxygen species,inhibition of lung cancer invasion and metastasis,reversal of lung cancer chemoresistance and so on.And it will provide new ideas for further study of the development of natural products and the discovery of anti-tumor innovative drugs.

关 键 词：天然产物 肺癌 机制 

分 类 号：Q319[生物学—遗传学]