生血增白汤对环磷酰胺致血虚小鼠RBC、Hb、WBC、Plt含量的影响  

Effects of Shengxue Zengbai Decoction on the RBC, Hb, WBC and Plt in Blood-Deficient Model Mice Induced by Cyclophosphamide

作　　者：邱云[1] 戎宽[1] 杨惠 毛果 刘天舒[1] 尹天雷[1] 匡建军[1] QIU Yun;RONG Kuan;YANG Hui;MAO Guo;LIU Tianshu;YIN Tianlei;KUANG Jianjun(The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China)

机构地区：[1]湖南省中医药研究院附属医院,湖南长沙410006 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖南中医药大学学报》2017年第12期1323-1325,共3页Journal of Hunan University of Chinese Medicine

基　　金：长沙市科技计划项目(kq1701166);湖南省中医药研究院院级课题(201312)

摘　　要：目的研究生血增白汤对环磷酰胺(CTX)致血虚小鼠RBC、Hb、WBC、Plt含量的影响,旨在探讨生血增白汤对化学性损伤血虚症的补血作用。方法取ICR小鼠60只,随机分为6组,即正常对照组(A组),模型对照组(B组),阳性药四物合剂组(C组),生血增白汤低、中、高剂量组(D1、D2、D3组),每组10只,连续给药8 d。除A组外,其他组小鼠每日均于给药后4 h注射环磷酰胺100 mg/kg,第8天给药后测全血红细胞(RBC)、血红蛋白(Hb)、白细胞(WBC)、血小板(Plt)值,并对数据进行统计学分析。结果 B组小鼠RBC、Hb、WBC、Plt含量较A组显著降低(P<0.01)。与B组比较,D3组能使血虚证小鼠Hb升高(P<0.05);D1、D2、D3组及C组能使血虚证小鼠WBC升高(P<0.01);D3组及C组能升高小鼠Plt(P<0.05)。结论生血增白汤对CTX致化学性损伤造成的血虚证模型小鼠具有补血作用。Objective To explore the enriching blood effect on chemical damage blood deficiency syndrome in mice through observing the influence of Shengxue Zengbai decoction on the RBC,Hb,WBC and Plt concentration in blood-deficient model mice induced by cyclophosphamide(CTX).Methods60ICR mice were randomLy divided into6groups,10in each group,the normal control group(group A),model control group(group B),Siwu mixture positive drug group(group C),low,medium and high dose groups of Shengxue Zengbai decoction(group D1,D2and D3),continuous administration for8days.All groups were injected with100mg of cyclophosphamide after administration of4h every day except group A.After eighth days of administration,the red blood cell(RBC),hemoglobin(Hb),white blood cell(WBC)and platelet(Plt)value in whole blood of all groups were measured,and carried on statistics analysis to its data.Results The levels of RBC,Hb,WBC and Plt in group B were significantly lower than that in group A(P<0.01).Compared with group B,the level of Hb markedly increased in group D3(P<0.05);the level of WBC increased in group D1,D2,D3and group C(P<0.01);and the level of Plt increased in group D3and group C(P<0.05).Conclusion Shengxue Zengbai decoction has enriching blood effect on the chemical damage blood-deficient model mice induced by cyclophosphamide.

关 键 词：生血增白汤 血虚证 环磷酰胺 血常规 

分 类 号：R285.5[医药卫生—中药学] R551[医药卫生—中医学]