长沙地区1386例NAFLD患者中医体质分布特征及其与生活方式的相关性研究  

Study on the Distribution Characteristics of TCM Constitution and Its Correlation with Lifestyle of 1386 NAFLD Patients in Changsha Area

作　　者：李红[1] 刘璇[2] 陈斌[2] 兰红勤[1] 李晓屏[3] 王国栋[2] 彭杰[2] LI Hong;LIU Xuan;CHEN Bin;LAN Hongqin;LI Xiaoping;WANG Guodong;PENG Jie(Health Management Center, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Center for Liver, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Center for preventive treatment of disease, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China)

机构地区：[1]湖南中医药大学第一附属医院健康管理中心,湖南长沙410007 [2]湖南中医药大学第一附属医院肝病中心,湖南长沙410007 [3]湖南中医药大学第一附属医院治未病中心,湖南长沙410007

出　　处：《湖南中医药大学学报》2017年第12期1358-1362,共5页Journal of Hunan University of Chinese Medicine

基　　金：湖南省中医药科研计划项目(2014154)

摘　　要：目的探索长沙地区非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)中医体质分布特征及其与生活方式的相关性。方法采取多阶段整群随机抽样的方法对来自于长沙地区工薪阶层的体检人群进行中医体质类型的抽样调查。结果1.NAFLD的中医体质分布如下:(1)第一体质构成比:平和质42.9%、痰湿质17.1%、湿热质10.2%、阳虚质9.9%、气虚质6.2%、阴虚质6.0%、气郁质4.5%、血瘀质1.9%、特禀质1.3%;(2)不同性别、年龄NAFLD患者的中医体质构成比不一(P<0.01);2.NAFLD主要中医体质与生活方式存在相关性:(1)痰湿质中保护因素:睡眠较好(Exp(β)=0.432,P=0.023);危险因素:很少运动(Exp(β)=2.524,P<0.01);(2)湿热质中保护因素:偶吸烟(Exp(β)=0.326,P=0.003)、不饮酒(Exp(β)=0.266,P<0.01)、偶饮酒(Exp(β)=0.487,P=0.011)、清淡饮食(Exp(β)=0.105,P=0.002);(3)阳虚质中保护因素:睡眠较好(Exp(β)=0.318,P=0.01);危险因素:很少运动(Exp(β)=4.378,P<0.01)。结论 1.长沙地区NAFLD患者中医体质分布以平和质、痰湿质、湿热质、阳虚质为主,存在兼夹体质;不同性别、年龄的NAFLD患者中医体质分布不同。2.NAFLD中医体质与饮食、烟酒、睡眠、运动关系密切,其中很少运动是体质最重要的影响因素。(1)痰湿质以偏咸及肉荤饮食、常饮酒、常失眠、很少运动为主;其中睡眠较好为保护因素,很少运动为危险因素;(2)湿热质以辛辣饮食、嗜烟酒、很少运动为主;其中少烟酒、清淡饮食为保护因素;(3)阳虚质以清淡饮食、常失眠为主;其中很少运动为危险因素,睡眠较好为保护因素。Objective To explore the distribution characteristics of TCM Constitution of nonalcoholic fatty liver(NAFLD)in Changsha area and its correlation with lifestyle.Methods Multi stage cluster random sampling method was adopted to investigate the physical fitness of the population in Changsha area.Results1.The distribution of TCM Constitution constituent with NAFLD as follows:(1)Constitution ratio of the first TCM constitution:flat constitution42.9%,phlegm-dampness constitution17.1%,damp-heat constitution10.2%,Yang deficiency constitution9.9%,Qi deficiency constitution6.2%,Yin deficiency constitution6.0%,Qi depression constitution4.5%,blood stasis constitution1.9%,special quality constitution1.3%.(2)NAFLD patients with different gender,age of TCM showed different co22(10):1800.nstitutions.2.The correlation between the main TCM constitutionin in patients with NAFLD and lifestyle are as follows:(1)The protection factors of phlegm dampness:sleep(Exp(β)=0.432,P=0.023),and risk factors:little movement(Exp(β)=2.524,P<0.01);(2)The protection factors of damp-heat:occasionally smoking(Exp(β)=0.326,P=0.003),no drinking(Exp(β)=0.266,P=0.01),occasional drinking(Exp(β)=0.487,P=0.011),light diet(Exp(β)=0.105,P=0.002);(3)The protection factors of Yang deficiency:sleep better(Exp(β)=0.318,P=0.01);risk factors:little movement(Exp(β)=4.378,P<0.01).Conclusion1.The main distribution of TCM constitution in patients with NAFLD in changsha was flat,phlegm-dampness,damp-heat,Yang deficiency,the mixed constitution also exsited.NAFLD patients with different gender,age of TCM showed different constitutions.2.NAFLD TCM Constitution has close relationship with diet,alcohol,sleep and exercise.The little exercise are the most important factors affecting the TCM constitution in patients with NAFLD.(1)Phlegm dampness is closed with salty meat and meat diet,often drink,often insomnia,little movement;Sleep better was the protective factor and little movement was the risk factor;(2)Damp heat is closed with spicy food,alcohol and tobacco use,litt

关 键 词：非酒精性脂肪肝 中医体质类型 生活方式 

分 类 号：R256.4[医药卫生—中医内科学] R575[医药卫生—中医学]