滋肾育胎丸联合克龄蒙治疗卵巢早衰的临床观察  

Clinical Effect of Zishen Yutai Pill Combined with Climen on Premature Ovarian Failure

作　　者：解娟[1] 陈明芳 XIE Juan;CHEN Mingfang(Department of Pharmacy, Shaanxi Province People's Hospital, Xi'an, Shaanxi 710068, China;The First Hospital of Hanbin District, Ankang, Shaanxi 725000, China)

机构地区：[1]陕西省人民医院药剂科,陕西西安710068 [2]安康市汉滨区第一医院,陕西安康725000

出　　处：《湖南中医药大学学报》2017年第12期1396-1399,共4页Journal of Hunan University of Chinese Medicine

基　　金：陕西省卫计委基金项目(2015D062)

摘　　要：目的探讨滋肾育胎丸联合克龄蒙治疗卵巢早衰(premature ovarian failure,POF)的临床疗效。方法将我院收治的78例POF患者随机平均分为观察组和对照组,对照组给予口服克龄蒙治疗;观察组在对照组治疗基础上给予口服滋肾育胎丸。2组治疗时间均为6个月。治疗后,评价2组疗效。治疗前后,分别观察2组烦躁易怒、潮热汗出、头晕耳鸣、腰膝酸软、失眠健忘等各项症状评分,并分别检测2组雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、子宫内膜厚度、卵巢动脉收缩期峰值流速(PSV)及平均卵巢直径(MOD)水平。治疗期间,密切观察2组患者出现的不良反应。结果治疗后,观察组总有效率为92.3%,明显高于对照组74.4%(P<0.05)。治疗后,观察组各项症状评分均明显低于对照组(P<0.05);其中,LH、FSH及E2含量改善程度均明显优于对照组(P<0.05);子宫内膜厚度、PSV及MOD水平均明显高于对照组(P<0.05)。治疗期间,所有患者均未出现严重不良反应。结论滋肾育胎丸联合克龄蒙治疗POF疗效确切,且能够有效改善患者激素水平,提高子宫功能。Objective To explore the clinical efficacy of Zishen Yutai pill combined with Climen in treatment of premature ovarian failure(POF).Methods78patients with POF in our hospital were randomly divided into control group(n=39)and observation group(n=39).The control group was given climen,while the observation group was given Zishen Yutai pill on the basis of control group.Both groups were treated for6months.After treatment,the effects in two groups were compared.The levels of symptom scores,including sweat,dizziness tinnitus,lumbar debility,insomnia,forgetfulness and irritability in the two groups were observed before and after treatment.The levels of E2,LH,FSH,endometrial thickness,PSV and MOD in the two groups were detected before and after treatment.The adverse actions in the two groups were observed.Results After treatment,the total effective rate92.3%in treatment group,significantly higher than that74.4%in control group(P<0.05).After treatment,the levels of symptom scores in observation group were significantly lower than control group(P<0.05).After the treatment,the levels of LH,FSH,E2were superior to the control group(P<0.05).The endometrial thickness,PSV and MOD levels in observation group were significantly higher than the control group(P<0.05).There were no serious adverse actions occurred in the patients.Conclusion The effect of Zishen Yutai pill combined with Climen in treatment of POF is exact,and could promote the hormone levels and uterine function in the patients.

关 键 词：卵巢早衰 滋肾育胎丸 克龄蒙 

分 类 号：R271.1[医药卫生—中医妇科学] R289.5[医药卫生—中医学]