平肺化瘀汤联合阿司匹林对COPD合并继发性红细胞增多症患者凝血功能、呼吸功能和运动耐量的影响  

Effect of Pingfei Huayu soup in combination with aspirin on coagulation function,respiratory function and exercise tolerance of COPD patients with secondary polycythemia

作　　者：张玉龙[1] Zhang Yulong(Baoji Chinese Medicine Hospital of Shaanxi Province,Baoji721000)

机构地区：[1]陕西省宝鸡市中医医院,宝鸡721000

出　　处：《陕西中医》2018年第1期53-55,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省自然科学基金资助项目(2016JM808)

摘　　要：目的:观察平肺化瘀汤联合阿司匹林对慢性阻塞性肺疾病(COPD)合并继发性红细胞增多症患者凝血功能、呼吸功能和运动耐量的影响。方法:将90例COPD合并继发性红细胞增多症患者随机分为两组,每组45例,两组均给予常规基础治疗,对照组在其基础上给予阿司匹林,观察组在对照组基础上给予自拟平肺化瘀汤治疗,疗程8周。观察两组治疗前后血液学、凝血功能、呼吸功能和运动耐力的变化情况。结果:两组治疗后RBC、Hb、EPO、Hct显著降低,观察组EPO、Hct低于对照组(P<0.05);两组治疗后APTT、Fib显著降低,观察组上述指标均低于对照组(P<0.05);两组治疗后FEV1/FVC、峰值呼吸流速(PEF)、肺一氧化碳弥散量(DLCO)均显著升高,观察组均高于对照组(P<0.05);两组治疗后6min步行试验距离(6MWD)分级和距离均显著提高,观察组的改善情况优于对照组(P<0.05)。结论:自拟平肺化瘀汤联合阿司匹林可显著降低COPD合并继发性红细胞增多症患者RBC、Hb、EPO、Hct,降低高凝状态,改善微循环和呼吸功能,从而提高运动耐量。Objective:To observe the effect of Pingfei Huayu soup in combination with aspirin on coagulation function,respiratory function and exercise tolerance of chronic obstructive pulmonary disease(COPD)patients with secondary polycythemia.Methods:90cases of COPD patients with secondary polycythemia were randomly divided into two groups with45cases in each,both groups received conventional treatments,control group received aspirin on the basis of routine treatment meanwhile observation group received Pingfei Huayu soup combined with aspirin for8weeks.Haematological indexes,coagulation function,respiratory function and exercise tolerance were observed in both groups before and after treatment.Results:RBC,Hb,EPO and Hct after treatment were markedly decreased in both groups,EPO and Hct of observation group were lower than those of control group(P<0.05),APTT and Fib after treatment were significantly decreased as compared with those before treatment in both groups(P<0.05),those indexes in observation group were lower than those in the control group(P<0.05).FEV1/FVC,peak expiratory flow(PEF)and diffusing capacity of the lungs for carbon monoxide(DLCO)after treatment in both groups were significantly higher than those before treatment,and these indexes in observation group were higher than the control group(P<0.05).classification and distance of6minute walking distance(6MWD)test were significantly improved after the treatment in both goups,and improvement of observation group was obviously better than the control group(P<0.05).Conclusion:The treatment of Pingfeihuayu soup combined with aspirin can significantly reduce RBC,Hb,EPO,Hct of COPD patients with secondary erythrocytosis,and reduce high coagulation state,improve microcirculation and respiratory function,so as to improve exercise tolerance.

关 键 词：肺疾病 慢性阻塞性/中西医结合疗法活 血祛瘀剂/治疗应用 @平肺化瘀汤 阿司匹林 

分 类 号：R563.9[医药卫生—呼吸系统]