口腔幽门螺杆菌感染与口腔扁平苔藓相关性的系统评价  

Correlation between oral Helicobacter pylori infection and oral lichen planus:a systematic review

作　　者：佘杨杨 梁毅舟 农晓琳[1] SHE Yangyang;LIANG Yizhou;NONG Xiaoling(Department of Oral and Maxillofacial Surgery,College and Hospitl of Stomatology,Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学口腔医学院口腔医院口腔颌面外科,南宁530021

出　　处：《国际检验医学杂志》2017年第24期3365-3367,3370,共4页International Journal of Laboratory Medicine

基　　金：广西研究生教育创新计划项目(201010598RY10,YCW2017117);广西高等教育本科教学改革工程立项项目(2016JGA161);广西医科大学教学质量工程与教学改革工程项目(2016JGG002)

摘　　要：目的系统评价口腔幽门螺杆菌(HP)感染与口腔扁平苔藓(OLP)之间的相关性。方法检索Pubmed、Embase、Cochrane Library、中国学术期刊全文数据库(CNKI)、万方、重庆维普网等数据库,纳入符合条件的病例对照研究。口腔HP的感染与OLP的关系采用合并比值比(OR)和相应的95%CI进行评价。使用STATA11.0对数据进行分析。根据异质性,采用固定或随机效应模型进行计算。结果共纳入7个病例对照研究,包含307例OLP患者和207例健康对照。分析结果显示:OLP患者与健康人群相比有更高的口腔HP感染率(OR=8.43,95%CI:2.90~24.52),差异有统计学意义(P<0.05)。结论 HP可能是OLP患病的危险因素,可以为OLP的防治提供新的策略。但受纳入文献质量的影响,尚需累积大样本的高质量的研究。Objective This study was performed to explore the association between oral Helicobacter pylori(HP)infection and oral lichen planus(OLP).Methods Some online electronic databases such as PubMed,Embase,Cochrane Library,CNKI,Wanfang and Chongqing VIP were searched for the eligible case control studies.The association between oral HP infection and OLP was estimated by the pooled odds ratios(OR)and95%confidence intervals(95%CI).Statistical analyses were performed by using STATA11.0software.Fixed or random effects model was used to calculate ORs and95%CI according to heterogeneity.Results A total of7studies with307patients and207healthy controls were included in the current study.The results of metaanalysis showed the patients with OLP had a significantly higher prevalence of oral HP infection compared with the healthy population(OR=8.43,95%CI:2.90-24.52,P<0.001).Conclusion This study suggested that HP may be a risk factor for OLP.These findings may guide new strategies for OLP therapy and prevention.However,due to the influence of the quality of the included literature,additional high quality of studies with larger sample sizes are needed.

关 键 词：幽门螺杆菌 口腔扁平苔藓 系统评价 病例对照研究 

分 类 号：R446.5[医药卫生—诊断学] R781.5[医药卫生—临床医学]