儿童自身免疫甲状腺病促甲状腺素受体抗体检测价值的探讨  

The investigation on the detection value of thyrotropin receptor antibody in children with autoimmune thyroid disease

作　　者：黄勇[1] HUANG Yong(Suining Hospital of Traditional Chinese Medicine of Suining Sichuan Province,Sichuan 629000,China)

机构地区：[1]四川省遂宁市中医院检验科,四川遂宁629000

出　　处：《国际检验医学杂志》2017年第24期3418-3419,3423,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨儿童自身免疫甲状腺病促甲状腺素受体抗体(TRAb)测定的临床应用价值。方法选择2015年1月至2016年10月该院收治的72例儿童自身免疫甲状腺病患儿,其中36例Graves病患儿作为Graves病组,36例桥本甲状腺炎患儿作为桥本甲状腺炎组;另选择同期在该院体检的健康儿童36例作为对照组。Graves病和桥本甲状腺炎患儿均进行常规治疗,观察两组患儿治疗前和治疗1年后血清TRAb水平变化。TRAb值阳性范围为>1.75U/L,统计两组患儿治疗前和治疗1年后血清TRAb阳性率。结果治疗前Graves病组TRAb[(12.79±6.38)U/L]水平高于桥本甲状腺炎组[(2.03±0.29)U/L]和对照组[(0.85±0.23)U/L],差异有统计学意义(P<0.05);桥本甲状腺炎组TRAb水平高于对照组,差异有统计学意义(P<0.05);治疗后Graves病组TRAb[(9.36±12.14)U/L]水平高于桥本甲状腺炎组[(1.78±0.38)U/L]和对照组[(0.84±0.29)U/L],组间比较差异有统计学意义(P<0.05);桥本甲状腺炎组TRAb水平显著高于对照组,组间比较差异有统计学意义(P<0.05);Graves病组和桥本甲状腺炎组治疗后TRAb水平均低于治疗前,差异有统计学意义(P<0.05);Graves病组治疗前后TRAb阳性率均为100%,桥本甲状腺炎组治疗后TRAb阳性率(11.11%)较治疗前(22.22%)下降,治疗前后比较差异有统计学意义(P<0.05)。结论儿童自身免疫甲状腺病存在明显TRAb指标变化,尤其是Graves病治疗前后TRAb指标明显变化,可为Graves病临床诊断和预后评估提供一定参考依据。Objective To investigate the detection value of thyrotropin receptor antibody(TRAb)in children with autoimmune thyroid disease.Methods During the January2015and October2016,a total of72cases of children with autoimmune thyroid disease admitted to our hospital were selected,including36cases of Graves disease as the Graves disease group,and36cases of Hashimoto's thyroiditis as Hashimoto's thyroiditis group;36cases of healthy children in this hospital at the same period were selected as the control group.Children in the Graves disease group and Hashimoto's thyroiditis group were taken routine treament,ane the changes of the serum TRAb level before the treatment and one year after the treatment between the two groups.The positive value range of TRAb level is more than1.75U/L,and the positive rate of serum TRAb level before the treatment and one year after the treatment was recorded in the two groups.Results Before treatment,TRAb level of the Graves disease group[(12.79±6.38)U/L]was higher than those in Hashimoto's thyroiditis group[(2.03±0.29)U/L]and the control group[(0.85±0.23)U/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group[(2.03±0.29)U/L]was significantly higher than that of the control group[(0.85±0.23)U/L],(P<0.05).After treatment:TRAb level of the Graves disease group[(9.36±12.14)U/L]was significantly higher than those in Hashimoto's thyroiditis group[(1.78±0.38)U/L]and the control group[(0.84±0.29)IU/L],and the difference was statistically significant(P<0.05);TRAb level of the Hashimoto's thyroiditis group was significantly higher than the control group,and the difference was statistically significant(P<0.05).TRAb levels in patients with graves'disease and Hashimoto thyroiditis after treatment were significantly lower than those before treatment,and the difference was statistically significant(P<0.05).The positive rates of TRAb level in the Graves disease group before and after treatment were100%,and the positive rate of TRAb level in Hashim

关 键 词：桥本甲状腺炎 GRAVES病 儿童自身免疫甲状腺病 促甲状腺素受体抗体 

分 类 号：R446.6[医药卫生—诊断学] R725.8[医药卫生—临床医学]