含胰岛素心肌保护液的心肌保护作用  

Myocardial protective effect of insulin-containing cardioplegia

作　　者：张社会[1] 马广耀[2] 曹东辉[3] 李永强[1] 张景玮[1] 郑贯峥 李宪营[1] She-hui Zhang;Guang-yao Ma;Dong-hui Cao;Yong-qiang Li;Jing-wei Zhang;Guan-zheng Zheng;Xian-ying Li(Department of Anesthesiology,Luohe,Henan 462000, China;Department of Cardiac Surgery,Luohe,Henan 462000, China;Department of Pathology, Luohe Central Hospital,Luohe,Henan 462000,China)

机构地区：[1]河南省漯河市中心医院麻醉科,河南漯河462000 [2]河南省漯河市中心医院心外科,河南漯河462000 [3]河南省漯河市中心医院病理科,河南漯河462000

出　　处：《中国现代医学杂志》2018年第8期98-103,共6页China Journal of Modern Medicine

摘　　要：目的研究含胰岛素心肌保护液对心内直视手术的心肌保护效果。方法体外循环心脏手术患者68例,随机分为A、B两组,每组34例,A组采用含胰岛素心肌保护液进行灌注,B组采用含血心肌保护液灌注。观察两组患者自动复跳率、血管活性药物的使用情况、心肌酶的变化和心肌超微结果的变化。结果 A组患者自动复跳率较高,心脏手术过程中停跳液只需灌注1次。两组手术前后心肌酶的变化和心肌细胞超微结构无差异。结论含胰岛素心肌保护液配制简单,心脏手术过程中灌注次数较少,心肌保护效果较好,缩短了手术时间。Objective To study the cardioprotective effect of cardioplegia containing insulin in open-heart surgery.Methods Sixty-eight patients undergoing open-heart surgery were randomly divided into group A and group B,each group had34patients.The patients in the group A were perfused with cardioplegia containing insulin,while those in the group B were perfused with cardioplegia containing blood.Then auto-rebeat rate of heart,use of vasoactive agents,changes of myocardial enzymes and myocardial ultrastructures were observed.Results The autorebeat rate of heart in the patients of the group A was higher,and cardioplegia was only needed to be perfused once in the heart surgery.There were no obvious differences in the changes of myocardial enzymes or the myocardialultrastructures between the two groups.Conclusions Cardioplegia containing insulin has the advantages of simple preparation,fewer times of perfusion in surgery,better protective effect and shorter operative time.

关 键 词：体外循环 心肌保护 胰岛素 心内直视手术 

分 类 号：R654.1[医药卫生—外科学]