慢阻肺合并肺源性心脏病心力衰竭老年患者心功能与sST2和NT-proBNP相关性分析  

Correlation analysis between sST2, NT-proBNP and cardiac function in elderly patients with COPD combined with cor pulmonale heart failure

作　　者：李敏[1] 靖颖霞[1] 李华桦 张义雄[1] LI Min;JING Ying-xia;LI Hua-hua;ZHANG Yi-xiong(Department of Emergency, Hunan General Hospital, Changsha 410000, China)

机构地区：[1]湖南省人民医院急诊科,长沙410000

出　　处：《中国医学前沿杂志（电子版）》2017年第12期105-109,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨慢性阻塞性肺疾病(慢阻肺)合并肺源性心脏病(肺心病)心力衰竭老年患者心功能与血清可溶性人基质裂解素2(soluble suppression of tumorigenesis 2,sST2)和N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)之间的相关性及期临床意义。方法选择2015年6月至2016年10月于湖南省人民医院住院的慢阻肺合并肺心病心力衰竭老年患者80例纳入试验组。选取同期湖南省人民医院40例健康体检者纳入对照组。检测所有入组研究对象血清sST2和NT-proBNP水平以及血脂、肾功能指标。结果试验组患者血清sST2和NT-proBNP水平均显著高于对照组(P<0.05),sST2和NT-proBNP水平随着心功能分级的增加而升高(P<0.05)。NT-proBNP和sST2水平与心功能分级均呈正相关(r=0.875,P<0.05;r=0.718,P<0.05),sST2与NT-proBNP水平之间存在较强的正相关性(r=0.796,P<0.05)。此外,sST2和NT-proBNP水平与血脂及肾功能指标均存在不同程度的相关性。结论慢阻肺合并肺心病心力衰竭患者血清sST2和NT-proBNP水平随着心力衰竭严重程度的增加而升高,并与肾功能和血脂水平有一定的相关性,因此,检测sST2和NT-proBNP水平有助于老年慢阻肺合并肺心病心力衰竭的诊断和预后判断。Objective To investigate the relationship between serum soluble suppression of tumorigenesis2(sST2),N-terminal pro-brain natriuretic peptide(NT-proBNP)and cardiac function in the elderly patients with chronic obstructive pulmonary disease(COPD)combined with cor pulmonale heart failure.Method80elderly patients with COPD combined with cor pulmonale heart failure in Hunan General Hospital from June2015to October2016were selected as experimental group.In addition,40healthy volunteers in that hospital were collected as control group.The levels of sST2,NT-proBNP,lipid,and renal function indexes weredetected.Result The levels of serum sST2and NT-proBNP of experimental group were significantly higher than those of control group(P<0.05),the levels of sST2and NT-proBNP were increased with the increase severity of heart failure.The levels of NT-proBNP and sST2were positively correlated with the classification of cardiac function(r=0.875,P<0.05;r=0.796,P<0.05).In addition,sST2and NT-proBNP were respectively correlated with lipid and renal function at the certain extent.Conclusion Serum levels of sST2and NT-proBNP in patients with COPD combined with cor pulmonale heart failure increase with the increase of heart failure severit,and have certain correlation with renal function and blood lipid,which is helpful to the diagnosis and prognosis of senile COPD combined with cor pulmonale heart failure.

关 键 词：慢性阻塞性肺疾病 肺源性心脏病 心力衰竭 生物标志物 老年患者 

分 类 号：R541.5[医药卫生—心血管疾病] R563.9[医药卫生—内科学]