慢性难治性溃疡的治疗  

The Treatment of Chronic Difficult Ulcer

作　　者：亓发芝 QI Fa-zhi(Department of Plastic Surgery,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院整形外科,上海200032

出　　处：《中国美容医学》2018年第2期2-4,1+160,共3页Chinese Journal of Aesthetic Medicine

基　　金：国家自然基金项目81671915,Kindlin-2调节整合素αⅤβ3活性对皮肤创伤愈合的作用和机制研究

摘　　要：临床上慢性难治性溃疡日益多见,严重影响人们生存质量,多见于下肢,其愈合影响因素为组织量不足和血液循环障碍。本文概述了创伤愈合的基本过程,针对不同的愈合阶段,详细论述了临床治疗方法,并结合文献,对慢性创面治疗的新方法进行了阐述。采用正确的对因治疗,及时有效地处理创面,随着功能性敷料的发展,水刀技术、VSD以及细胞治疗的广泛应用,可有效提高下肢慢性难治性溃疡的治疗效果。The chronic difficult ulcers such as lower limb venous ulcer,pressure sore,and diabetic foot have increasing dramatically with the coming of elderly society.It has been one of the significant diseases which affect the quality-of-life in older people.The chronic difficult ulcers located at the lower limb most frequently.The main reasons are local soft tissue deficiency and blood supply impairment.We introduced the pathophysiology of normal wound healing,and the clinical treatment of the chronic ulcers according to the pathological stage.The advancement of the treatment was also presented.The proper etiologic treatment and effective wound prepare are key points of the success treatment.The water-jet debridement,VSD preparation,stem cell treatment,PRP and the combination of autologous fat transfer and skin graft were also introduced in detail.

关 键 词：慢性溃疡 糖尿病足 老烂脚 植皮 皮瓣 

分 类 号：R632.1[医药卫生—外科学]