黄体酮阴道缓释凝胶在FET周期不同内膜准备方案中黄体支持的效果分析  

Effects of progesterone sustained-release vaginal gel for luteal phase support in different endometrial preparation schemes for frozen-thawed cycle

作　　者：许科[1] 陈莉[1] 陈洋[1] 黄晓阳[1] XU Ke;CHEN Li;CHEN Yang;HUANG Xiao-yang(Reproductive Center,Changzhou Maternal & Child Healthcare Hospital,Nanjing Medical University,Changzhou 213000)

机构地区：[1]南京医科大学附属常州市妇幼保健院生殖中心,常州213000

出　　处：《生殖医学杂志》2018年第3期232-236,共5页Journal of Reproductive Medicine

基　　金：常州市卫生计生局指导课题(WZ201621)

摘　　要：目的分析黄体酮阴道缓释凝胶在冻融胚胎移植(FET)周期不同内膜准备方案中黄体支持的效果。方法回顾性分析2015年10月至2017年5月本院生殖中心260例激素替代FET周期患者(A组)及300例自然周期FET患者(B组)临床资料,并根据不同黄体支持方式将患者分为A1组(黄体酮针剂+地屈孕酮,186例)、A2组(黄体酮阴道缓释凝胶+地屈孕酮,74例)、B1组(黄体酮针剂+地屈孕酮,234例)、B2组(黄体酮阴道缓释凝胶+地屈孕酮,66例)。比较同一周期不同黄体支持方式黄体支持效果及妊娠情况。结果两种不同内膜准备方案组内不同黄体支持方式亚组(A1组与A2组、B1组与B2组)患者间年龄、体重指数(BMI)、不孕年限、移植日内膜厚度、移植优胚数等均无统计学差异(P>0.05);A2组的临床妊娠率、持续妊娠率均显著高于A1组(分别为58.11%vs.40.86%,50.00%vs.36.02%)(P<0.05),而B2组与B1组比较,临床妊娠率及持续妊娠率均无统计学差异(分别为42.42%vs.40.60%,39.39%vs.37.18%)(P>0.05)。结论激素替代周期FET患者使用黄体酮阴道缓释凝胶进行黄体支持,有利于改善临床妊娠率。To analyze the effect of progesterone sustained-released vaginal gel(Crinone8%)for luteal phase support in frozen-thawed embryo transfer(FET)in different endometrial preparation.Methods:The clinical data of260patients undergone hormone replacement FET cycles(group A)and300patients undergone natural FET cycles(group B)in our Reproduction Center from October2015to May2017were retrospective analyzed.According to the luteal phase support regimen,the patients in group A were further assigned to the progesterone injection and dydrogesterone tablets group(group A1,n=186)or progesterone sustained-release vaginal gel and dydrogesterone tablets group(group A2,n=74).The patients in group B were further assigned to the progesterone injection and dydrogesterone tablets group(group B1,n=234)or progesterone sustained-release vaginal gel and dydrogesterone tablets group B2(group B2,n=66).The effects of luteal phase support and pregnancy status in the same FET cycle were compared among the different luteal phase support regimens group.Results:There were no significant differences in age,BMI,duration of infertility,endometrial thickness on the day of transfer,and number of high quality embryos between group A1and A2&group B1and B2(P>0.05).The clinical pregnancy rate(58.11%vs.40.86%)and continuous pregnancy rate(50.00%vs.36.02%)in group A2were significantly higher than those in group A1(P<0.05),but the differences of clinical pregnancy rate(42.42%vs.40.60%)and continuous pregnancy rate(39.39%vs.37.18%)were not significant between group B1and B2embryos(P>0.05).Conclusions:Progesterone sustained-release vaginal gel can be used for luteal phase support in FET cycle,which is favorable for improving the clinical pregnancy rate.

关 键 词：冻融胚胎移植 黄体酮阴道缓释凝胶 激素替代 黄体支持 

分 类 号：R714.8[医药卫生—妇产科学]