智能放射吸收法的临床应用——人体手臂骨骨密度的测量及其骨质疏松的评估  

Clinical Application of Intelligent Radiographic Absorptiometry–Human Forearm's Bone Mineral Measurements and the Osteoporosis Assessments

作　　者：陈建锋 范运洲 李鹏 黄松正 CHEN Jianfeng;FAN Yunzhou;LI Peng;HUANG Songzheng(Department of Radiology,Feinberg School of Medicine,Northwestern University,Chicago Illinois 60611,USA;Department of Research and Development,Zhejiang Kangyuan Medical Devices Incorporation,Hangzhou Zhejiang 310051,China)

机构地区：[1]西北大学医学院放射科,美国伊利诺州芝加哥60611 [2]浙江康源医疗器械有限公司研发部,浙江杭州310051

出　　处：《中国医疗设备》2018年第3期31-35,69,共6页China Medical Devices

摘　　要：目的本文介绍了一种称为智能放射吸收法的骨密度测量方法,并给出了测量结果。方法首先,在228名男女受试者的前臂上采集了数字放射(Digital Radiography,DR)图像,然后用智能放射吸收法(Intelligent Radiographic Absorptiometry,i-RA)处理这些DR图像。选取距离非优势侧前臂超远端1/3桡骨长处的桡骨区域(简称1/3区域)为我们测量骨密度的区域,并将智能放射吸收法与双能量X-射线吸收法(Dual X-ray Absorptiometry,DXA)测量所获得的骨密度值和T-值分别进行Pearson相关性、以及ROC曲线分析计算。结果与使用DXA的测量结果进行比较,该方法已被广泛应用于骨密度值(Bone Mineral Density,BMD)测量,并被定义为世界卫生组织黄金标准,临床试验结果显示相关系数:r=0.984(基于BMD值),及r=0.979(基于T-值),灵敏度为98.5%,特异度为98.2%,ROC曲线下的面积为0.998。结论这些统计分析结果显示,本文的智能RA测量法可替代传统的双能X-射线吸收法DXA的骨密度仪,来对人体前臂桡骨1/3部位处骨密度进行临床检测,及其骨质疏松症的评估。Objective In this paper,a bone mineral measurement method called intelligent radiographic absorptiometry(i-RA)was described and the measurement results were presented.Methods Firstly,digital radiography(DR)images were acquired from 228 human volunteers’forearms in vivo,then the i-RA method was used to process these DR images,the algorithm automatically placed the region of interest on the radius centered at 1/3 of the non-dominant forearm length measured from the styloid process on the ulna,both values of the bone mineral density(BMD)and T-score of these regions were determined.Results By comparing with the measurement results with using dual-energy X-ray absorptiometry(DXA),which had been widely used for BMD measurements and was defined as World Health Organization gold standard,the measurement results showed that the Pearson’s correlation coefficients were 0.984 for BMD,and 0.979 for T-scores,and the ROC results showed that sensitivity was 98.5%,specificity was 98.2%,area under curve was 0.998.Conclusion DXA method can be potentially replaced by the i-RA method to measure human radius’BMD and T-scores,and to diagnose osteoporosis.

关 键 词：智能放射吸收法 双能量X-射线吸收法 桡骨骨密度 T-值 

分 类 号：R816[医药卫生—放射医学]