盐酸丁卡因的合成工艺研究  

Synthesis Process Research of Tetracaine Hydrochloride

作　　者：李文丽[1] 赵杰[1] 崔玉洁 Li Wenli;Zhao Jie;Cui Yujie(Chong Qing Energy College, Petroleum Chemical Testing Center, Chongqing, 402260;Depp Medical Technology Chemical Co.Ltd, Shandong, 250000)

机构地区：[1]重庆能源职业学院石油化工检测中心,重庆402260 [2]德普顿斯医药技术有限公司,山东250000

出　　处：《当代化工研究》2017年第11期36-37,共2页Modern Chemical Research

基　　金：重庆市教委科学技术研究项目(批准号:KJ1505501)

摘　　要：丁卡因在1928年由Firsleb首先通过实验合成,盐酸丁卡因胶浆在1988年获得FDA批准上市,是一种长效酯类局部麻醉药,具有性质稳定、作用迅速、维持时间长等优点。本文主要介绍盐酸丁卡因的合成方法,为盐酸丁卡因的合成工艺开发和工业应用提供了参考。Tetracaine was firstly synthesized by Firsleb in1928,and Tetracaine Mucilage was approved by FDA in1988.Tetracaine Hydrochloride was a kind of long-termester local anesthetics,which had many advantages,such as stable physical and chemical properties,fast action,working a long time.This paper mainly introduces the synthesis methods of tetracaine hydrochloride,which provided data for the development and industrial application of the drug.

关 键 词：盐酸丁卡因 合成工艺 麻醉药 

分 类 号：O625.41[理学—有机化学]