益脑增智针法联合Bobath疗法治疗手足徐动型脑瘫患儿的临床疗效  

Clinical Effect of Yinao-zengzhi Acupuncture Therapy Combined with Bobath Exercise Rehabilitation Therapy in Treating Children with Athetosic Type Cerebral Palsy

作　　者：廖薇[1] 高炜燕[2] 张小利 艾坤[4] LIAO Wei;GAO Wei-yan;ZHANG Xiao-li;AI Kun(Center for Disease Control and Prevention,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530022,China;College of Acupuncture and Moxibustion,Guangxi University of Traditional Chinese Medicine,Nanning 530022,China;Department of Pediatrics,Nanning Hospital of Traditional Chinese Medicine,Nanning 530022,China;Hu'nan University of Traditional Chinese Medicine,Changsha 412800,China)

机构地区：[1]广西中医药大学第一附属医院治未病中心,广西壮族自治区南宁市530022 [2]广西中医药大学针灸推拿学院,广西壮族自治区南宁市530001 [3]广西壮族自治区南宁市中医医院儿科,530001 [4]湖南中医药大学,湖南省长沙市412800

出　　处：《实用心脑肺血管病杂志》2018年第1期81-85,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：湖南省中医药科研计划项目重点课题(201611)

摘　　要：目的观察益脑增智针法联合Bobath疗法治疗手足徐动型脑瘫患儿的临床疗效。方法选取2014年3月—2016年3月广西中医药大学第一附属医院收治的手足徐动型脑瘫患儿104例,采用随机数字表法分为对照组与观察组,每组52例。对照组患儿予以Bobath疗法,观察组患儿予以益脑增智针法联合Bobath疗法;两组患儿均连续治疗6个月。比较两组患儿临床疗效和治疗前后精细运动发育商(FMQ)评分、Caroll手功能评定量表评分、日常生活能力量表(ADL)评分、智力发育量表评分、CD_4^+CD_(25)^+Foxp3 high调节性T细胞比例、Foxp3 mRNA相对表达量、CTLA-4 mRNA相对表达量、血清白介素10(IL-10)水平、血清肿瘤坏死因子α(TNF-α)水平,并观察治疗后临床症状发生情况。结果观察组患儿临床疗效优于对照组(P<0.05)。治疗前两组患儿FMQ评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿FMQ评分高于对照组(P<0.05)。治疗前两组患儿Caroll手功能评定量表评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿Caroll手功能评定量表评分高于对照组(P<0.05)。治疗前两组患儿ADL评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿ADL评分高于对照组(P<0.05)。治疗前两组患儿智力发育量表评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿智力发育量表评分高于对照组(P<0.05)。治疗前两组患儿CD_4^+CD_(25)^+Foxp3 high调节性T细胞比例、Foxp3 mRNA相对表达量、CTLA-4 mRNA相对表达量比较,差异无统计学意义(P>0.05);治疗后观察组患儿CD_4^+CD_(25)^+Foxp3 high调节性T细胞比例、Foxp3 mRNA相对表达量、CTLA-4 mRNA相对表达量低于对照组(P<0.05)。治疗前两组患儿血清IL-10、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后观察组患儿血清IL-10水平高于对照组,血清TNF-α水平低于对照组(P<0.05)。治疗后观察组患儿临床症状发生率低于对照组(P<0.05)Objective To observe the clinical effect of yinao-zengzhi acupuncture therapy combined with Bobath exercise rehabilitation therapy in treating children with athetosic type cerebral palsy.Methods A total of104children with athetosic type cerebral palsy were selected in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from March2014to March2016,and they were divided into control group and observation group according to random number table,each of52cases.Children in control group received Bobath exercise rehabilitation therapy,while children in observation group received yinao-zengzhi acupuncture therapy combined with Bobath exercise rehabilitation therapy;both groups continuously treated for6months.Clinical effect,FMQ score,Caroll Hand Function Rating Scale score,ADL score,Intelligence Development Scale score,CD4+CD25+Foxp3high T-regulatory cells ratio,relative expression quantity of Foxp3mRNA and CTLA-4mRNA,serum levels of IL-10and TNF-αbefore and after treatment were compared between the two groups,and incidence of clinical symptoms was observed after treatment.Results Clinical effect in observation group was statistically significantly better than that in control group(P<0.05).No statistically significant differences of FMQ score was found between the two groups before treatment(P>0.05),while FMQ score in observation group was statistically significantly higher than that in control group after treatment(P<0.05).No statistically significant differences of Caroll Hand Function Rating Scale score was found between the two groups before treatment(P>0.05),while Caroll Hand Function Rating Scale score in observation group was statistically significantly higher than that in control group after treatment(P<0.05).No statistically significant differences of ADL score was found between the two groups before treatment(P>0.05),while ADL score in observation group was statistically significantly higher than that in control group after treatment(P<0.05).No statistically significant differenc

关 键 词：脑性瘫痪 儿童 益脑增智针法 BOBATH疗法 治疗结果 

分 类 号：R682.22[医药卫生—骨科学]