儿童血钙联合化学发光法血清维生素D及骨碱性磷酸酶检测在佝偻病诊断中的应用价值  

The application value of blood calcium combined with serum vitamin D and bone alkaline phosphatase(BALP) by chemiluminescence in the diagnosis of rickets in children

作　　者：何小媚 罗裕旋 吴传安 杨伟康 HE Xiaomei;LUO Yuxuan;WU Chuanan;YANG Weikang(Center for Disease Control and Prevention of Longhua District, Guangdong, Shenzhen 518109, China;Longhua District Maternal and Child Health Hospital of Shenzhen City, Guangdong, Shenzhen 518109, China)

机构地区：[1]深圳市龙华区疾病预防控制中心,广东深圳518109 [2]深圳市龙华区妇幼保健院,广东深圳518109

出　　处：《中国医药科学》2018年第4期47-50,共4页China Medicine And Pharmacy

摘　　要：目的探讨儿童维生素D缺乏性佝偻病应用全血钙联合骨碱性磷酸酶(BALP)检测的价值。方法选取来我院进行体检的疑似维生素D缺乏性佝偻病儿童380例作为本次观察对象,体检时间均在2013年6月~2016年6月期间。在观察对象同意的情况下,所有儿童均进行全血钙、骨碱性磷酸酶(BALP)检测。将单纯全血钙检查结果划分为全血钙组,单纯BALP检测为BALP组,全血钙联合BALP检测称之为联合组。将两种不同检查方式的检查结果进行对比。结果 BALP组在不同年龄间差异具有统计学意义,BALP组中,男女性别间的检查结果差异无统计学意义(P>0.05)。全血钙组中,不同年龄间和男女性别间的检查结果差异均无统计学意义(P>0.05),维生素D组的检出率为52.11%,联合组的检出率为94.74%,明显优于其他两组(P<0.05);BALP>250U/L患儿的夜惊、多汗、枕秃、颅骨软化等临床症状发生率均高于200~250U/L患儿(P<0.05)。结论对于儿童维生素D缺乏性佝偻病,应用全血钙联合骨碱性磷酸酶(BALP)检测方式相较于单纯全血钙检测的敏感性更高,具有较高的临床使用价值。Objective To explore the value of whole blood calcium combined with bone alkaline phosphatase(BALP)in children with vitamin D deficiency rickets.Methods380cases of suspected vitamin D deficient rickets with physical examination from June2013to June2016in our hospital were selected as the subjects.In the case of the consent of the object,all children were tested for whole blood calcium and bone alkaline phosphatase(BALP).The patients with pure blood calcium were selected as the whole blood calcium group,the patients with the simple BALP test were selected as group BALP,the patients with the whole blood calcium combined with BALP were selected as the combined group.The results of two different examination methods were compared.Results In group BALP,the difference between different ages was statistically significant,and there was no statistically significant difference in the results of examination between men and women(P>0.05).In the whole blood calcium group,there was no significant difference in the results of examination between different ages and between men and women(P>0.05).The detection rate of vitamin D group was52.11%,and the detection rate in the combined group was94.74%,which was obviously better than the other two groups(P<0.05);The incidence rate such as night terrors,sweating,bald,craniotabes in children with BALP>250U/L were significantly higher than those in children with200-250U/L,(P<0.05).Conclusion For children with vitamin D deficiency rickets,the detection of whole blood calcium combined with bone alkaline phosphatase(BALP)is more sensitive than pure blood calcium detection,and has high clinical value.

关 键 词：儿童血钙 血清维生素D 全血钙 BALP 佝偻病 

分 类 号：R723[医药卫生—儿科]