间充质干细胞通过旁分泌治疗急性肺损伤的机制  

Mechanism of using mesenchymal stem cells to treat acute lung injury through paracrine pathway

作　　者：张琦 帅训军[2] 侯念果[2] 艾登斌[2] Zhang Qi;Shuai Xunjun;Hou Nianguo;Ai Dengbin(Department of Anesthesiology, Taishan Medical College, Taian 271000;Department of Anesthesiology, Qingdao Municipal Hospital, Shandong Province, Qingdao Clinical Anesthesia Research Center, Qingdao 266000, China)

机构地区：[1]泰山医学院研究生院临床麻醉学教研室,泰安271000 [2]山东省青岛市市立医院麻醉科,山东省青岛市临床麻醉研究中心,青岛266000

出　　处：《中国组织化学与细胞化学杂志》2018年第1期87-91,共5页Chinese Journal of Histochemistry and Cytochemistry

基　　金：青岛市医疗卫生优秀人才培养项目(青卫科教字[2014])

摘　　要：近年来急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS),病死率高达40%,越来越得到临床及科研工作者的重视。ALI/ARDS发病终末阶段,患者临床表现持续性难治性呼吸困难,依赖机械通气从而并发敏感性多器官功能障碍,最终死于呼吸衰竭。而降低肺损伤严重程度的药物疗法,至今尚未转化为临床治疗的可选择手段,因此仍需进行大量实验研究,开发安全、高效的治疗药物及诊疗方法。面对这一亟待解决、威胁全人类的健康问题,中外研究者在动物实验中发现干细胞可以根据需要,选择性修复身体受伤部位,来源广泛的间充质干细胞将有望成为人体损伤器官修复的最新"工具箱"。尽管面对ALI/ARDS持续升高的病死率,我们仍然有信心寄希望于干细胞组织修复的治疗技术。Acute lung injury(ALI)or acute respiratory distress syndrome(ARDS)has a mortality rate as high as40%.In the terminal stage of ALI/ARDS,patients have to rely on mechanical ventilation due to persistent refractory dyspnea,which leads to multiple organ dysfunction,eventually respiratory failure and death.Although in recent years,increasing amount of interest from both clinical and basic research scientists has been focused in this area,there is no effective drug treatment that can be applied to alleviate the severity of lung injury clinically.The need to develop safe and effective therapeutic drugs and treatment methods is urgent.For the reason,Chinese and foreign researchers explored the potential of stem cells and found that in animal models stem cells can selectively repair the injured tissues as needed.Furthermore,a wide range of mesenchymal stem cells from different sources may become the new"toolbox"to repair damaged organs.Despite the increasingly high mortality rate of ALI/ARDS,the utilization of stem cell for tissue repair looks promising.

关 键 词：干细胞 肺损伤 微泡 角质形成细胞生长因子 线粒体 

分 类 号：R563.8[医药卫生—呼吸系统]