前列腺特异抗原、前列腺酸性磷酸酶与前列腺癌患者饮食结构的关系探究  

A Study on the Correlation of the Levels of PSA and PAP and the Dietary Structure in Patients with Prostate Cancer

作　　者：王婷[1] 刘振华[1] 李雪黎[1] 陈叶[1] 马瑞[1] Wang Ting;Liu Zhenhua;Li Xueli;Chen Ye;Ma Rui(Department of Urology/Department of Urology Research Institute, West China Hospital of Sichuan University, Chengdu 610000, China)

机构地区：[1]四川大学华西医院泌尿外科/泌尿外科研究所,成都610000

出　　处：《成都医学院学报》2017年第6期690-693,698,共5页Journal of Chengdu Medical College

基　　金：四川省科技厅支撑项目(No:2014JY0085)

摘　　要：目的探讨前列腺特异抗原(prostate specific antigen,PSA)、前列腺酸性磷酸酶(prostatic acid phosphatase,PAP)与前列腺癌患者饮食结构的相关性,为前列腺癌患者饮食结构提供依据。方法选取2014年2月至2016年12月四川大学华西医院泌尿外科收治的180例前列腺癌患者为研究对象,作为试验组,同期选择120例前列腺炎患者为对照组,采用发光法检测PSA,放射免疫法检测PAP,比较两组PSA、PAP水平,并采用膳食结构问卷调查对两组对象进行饮食结构分组,分析PSA、PAP与饮食结构的相关性。结果试验组PSA、PAP依次是(10.54±1.35)ng/mL、(14.08±0.94)μg/L,均明显高于对照组(5.02±0.83)ng/mL、(6.56±0.79)μg/L,差异有统计学意义(P<0.05);试验组面粉、谷类摄入量明显低于对照组,畜禽肉类、食用油及盐摄入量明显高于对照组(P<0.05);经因子分析得出5种膳食模型:优质蛋白质模式、地中海模式、传统模式、调味品模式和西方模式,分析此5种饮食模式与PSA、PAP水平关系,显示PSA与饮食模式1、模式2呈负相关(B=-0.387,P=0.027;B=-3.812,P<0.001),与模式4、模式5呈正相关(B=0.763,P<0.001;B=0.531,P<0.001),与模式3无明显相关性(B=0.483,P=0.083);PAP与饮食模式无明显相关性(P>0.05)。结论前列腺癌患者多进食高脂肪、高热量、低纤维素食品,以西方膳食结构、调味品膳食结构为主,其机体PSA、PAP明显升高,且PSA与西方膳食结构、调味品膳食结构呈正相关,与优质蛋白质膳食结构、地中海膳食结构呈负相关,PAP则无明显相关性。Objective To investigate the correlation between the levels of the prostate specific antigen(PSA)and prostatic acid phosphatase(PAP)and the dietary structure in patients with prostate cancer and provide the evidence for the dietary structure of patients with prostate cancer.Methods A total of180prostate cancer patients admitted into the urology surgery of West China Hospital of Sichuan University from February of2014to December of2016were selected into the experiment group.The other120cases with prostate cancer over the corresponding period were selected into the control group.The luminescent method was used to detect PSA and the radioimmunoassay method was adopted to detect PAP.Then the levels of PSA and PAP were compared.The dietary structure questionnaire was used to investigate the dietary structure of two groups and the correlation between the levels of PAS and PAP and the dietary structure was analyzed.Results The levels of PSA and PAP in the experiment group were(10.54±1.35)ng/mL and(14.08±0.94)μg/L respectively and they were significantly higher than those in the control group which were(5.02±0.83)ng/mL and(6.56±0.79)μg/L respectively(P<0.05).The intakes of flour and cereal in the experiment group were significantly lower than those in the control group(P<0.05),while the intakes of the livestock and poultry meat,edible oil and salt in the experiment group were significantly higher than those in the control group(P<0.05).Five kinds of dietary models were obtained by the factor analysis and they were the high-quality protein model,Mediterranean model,traditional model,condiment model,and western model.The correlation between the five dietary models and the levels of PSA and PAP were analyzed and the results showed that PSA was correlated negatively with the high-quality protein model(B=-0.387,P=0.027)and Mediterranean model(B=-3.812,P<0.001)respectively,and correlated positively with the condiment model(B=0.763,P<0.001)and western model(B=0.531,P<0.001),and there was no correlation between PSA and the

关 键 词：前列腺癌 前列腺特异性抗原 酸性磷酸酶 饮食结构 

分 类 号：R69[医药卫生—泌尿科学]